Amino Acid Conservation Scores =============================== - POS: The position of the AA in the SEQRES derived sequence. - SEQ: The SEQRES derived sequence in one letter code. - 3LATOM: The ATOM derived sequence in three letter code, including the AA's positions as they appear in the PDB file and the chain identifier. - SCORE: The normalized conservation scores. - COLOR: The color scale representing the conservation scores (9 - conserved, 1 - variable). - CONFIDENCE INTERVAL: When using the bayesian method for calculating rates, a confidence interval is assigned to each of the inferred evolutionary conservation scores. - CONFIDENCE INTERVAL COLORS: When using the bayesian method for calculating rates. The color scale representing the lower and upper bounds of the confidence interval. - MSA DATA: The number of aligned sequences having an amino acid (non-gapped) from the overall number of sequences at each position. - RESIDUE VARIETY: The residues variety at each position of the multiple sequence alignment. POS SEQ 3LATOM SCORE COLOR CONFIDENCE INTERVAL CONFIDENCE INTERVAL COLORS MSA DATA RESIDUE VARIETY (normalized) 1 G GLY1:A -1.127 9 -1.315,-1.067 9,8 98/202 S,Q,K,G,E,L 2 V VAL2:A -0.532 7 -0.719,-0.312 7,6 106/202 I,R,L,V 3 Q GLN3:A 1.896 1 2.136, 2.136 1,1 105/202 A,S,F,T,N,K,E,V,Q,M,R,I,G,L 4 V VAL4:A -0.442 6 -0.593,-0.312 7,6 138/202 F,S,T,K,E,Y,V,Q,C,R,I,G 5 E GLU5:A 0.768 3 0.578, 1.023 3,2 158/202 A,F,S,T,N,K,E,V,Q,C,D,I,R,L 6 T THR6:A 0.526 3 0.277, 0.578 4,3 164/202 F,S,T,N,K,Y,E,V,Q,M,L,A,P,H,D,R,I 7 I ILE7:A 1.722 1 1.023, 2.136 2,1 169/202 S,A,F,T,N,K,Y,E,V,H,Q,D,I,R,L 8 S SER8:A 2.131 1 2.136, 2.136 1,1 173/202 S,A,W,T,N,K,P,E,V,H,Q,D,R,I,L 9 P PRO9:A 2.083 1 2.136, 2.136 1,1 173/202 F,S,T,K,Y,E,V,Q,M,C,L,A,W,P,D,R,I,G 10 G GLY10:A -0.023 5 -0.146, 0.045 5,5 174/202 F,A,S,T,N,X,K,P,E,V,Q,D,R,G 11 D ASP11:A 2.136 1 2.136, 2.136 1,1 189/202 F,S,T,N,K,Y,E,V,Q,L,A,P,H,D,R,I,G 12 G GLY12:A -0.123 5 -0.312, 0.045 6,5 191/202 A,S,T,N,K,E,V,Q,D,C,R,G 13 R ARG13:A 2.135 1 2.136, 2.136 1,1 200/202 A,S,T,W,N,P,K,Y,E,V,H,Q,D,R,G,L 14 T THR14:A 0.614 3 0.277, 1.023 4,2 123/202 A,S,T,N,K,E,V,Q,D,I,R,G,L 15 F PHE15:A 1.862 1 2.136, 2.136 1,1 179/202 F,S,T,N,K,Y,E,V,Q,M,C,L,A,P,H,R,I,G 16 P PRO16:A -0.557 7 -0.719,-0.459 7,6 201/202 S,A,T,K,P,V,C,I,L 17 K LYS17:A 1.983 1 2.136, 2.136 1,1 201/202 A,S,T,N,P,K,E,V,H,Q,M,D,R,G,L 18 R ARG18:A 2.136 1 2.136, 2.136 1,1 202/202 F,S,T,N,K,Y,E,V,Q,M,L,A,P,D,R,I,G 19 G GLY19:A -0.445 6 -0.593,-0.312 7,6 202/202 A,S,T,N,K,P,E,D,G,L 20 Q GLN20:A -0.514 7 -0.593,-0.459 7,6 202/202 F,A,S,T,N,K,P,Y,V,Q,M,C,D,G 21 T THR21:A 1.440 1 1.023, 2.136 2,1 202/202 A,S,F,T,N,P,K,Y,E,V,Q,M,R,I,G,L 22 C CYS22:A -0.927 8 -1.067,-0.837 8,8 202/202 A,M,C,I,L,V 23 V VAL23:A 0.686 3 0.578, 1.023 3,2 202/202 F,S,T,N,K,Y,E,V,Q,M,L,A,H,D,R,I,G 24 V VAL24:A -0.678 7 -0.837,-0.593 8,7 202/202 F,A,Y,V,M,C,I,L 25 H HIS25:A -1.133 9 -1.186,-1.067 9,8 202/202 A,W,N,K,E,Y,H,D,R 26 Y TYR26:A -1.057 8 -1.186,-0.953 9,8 202/202 F,C,I,L,Y 27 T THR27:A 0.318 4 0.045, 0.578 5,3 202/202 A,S,T,N,K,E,V,Q,D,R,I,L 28 G GLY28:A -1.217 9 -1.315,-1.186 9,9 202/202 S,A,M,T,C,R,G 29 M MET29:A 0.894 2 0.578, 1.023 3,2 202/202 F,S,T,W,K,E,Y,V,M,C,R,L 30 L LEU30:A -0.233 6 -0.459,-0.146 6,5 202/202 F,K,Y,V,H,C,I,G,L 31 E GLU31:A 0.506 3 0.277, 0.578 4,3 202/202 S,T,N,K,Y,E,V,Q,M,L,A,W,P,D,R,I,G 32 D ASP32:A -0.407 6 -0.593,-0.312 7,6 125/202 S,Q,T,M,D,N,K,G,E 33 G GLY33:A -1.165 9 -1.315,-1.067 9,8 202/202 S,N,D,K,G,E 34 K LYS34:A 0.199 4 0.045, 0.277 5,4 202/202 A,S,T,N,K,E,V,H,Q,D,I,R,L 35 K LYS35:A 0.620 3 0.277, 1.023 4,2 202/202 A,F,T,K,P,E,Y,V,Q,M,R,I,G,L 36 F PHE36:A -1.297 9 -1.315,-1.186 9,9 202/202 A,F,I,L,V 37 D ASP37:A -0.830 8 -0.953,-0.719 8,7 201/202 A,S,F,W,N,P,E,Y,H,Q,D,L 38 S SER38:A -1.013 8 -1.067,-0.953 8,8 176/202 A,S,T,N,K,Q,D,C,R,G 39 S SER39:A -1.186 9 -1.315,-1.067 9,8 122/202 A,S,Q,T,N,K 40 R ARG40:A 1.172 1 1.023, 1.023 2,2 121/202 F,S,N,K,Y,E,V,Q,C,L,A,W,H,R,I,G 41 D ASP41:A 0.050 5 -0.146, 0.277 5,4 194/202 A,S,F,T,N,P,K,E,V,H,D,R,I,G,L 42 R ARG42:A 0.019 5 -0.146, 0.277 5,4 194/202 A,S,T,N,P,K,Y,E,Q,R,L 43 N ASN43:A -0.087 5 -0.312, 0.045 6,5 193/202 A,S,N,K,P,E,Q,M,D,R,G 44 K LYS44:A 1.687 1 1.023, 2.136 2,1 195/202 S,A,T,N,P,K,E,V,H,Q,D,R,G,L 45 P PRO45:A -0.373 6 -0.459,-0.312 6,6 197/202 S,A,T,N,K,P,E,D,G,L 46 F PHE46:A 0.761 3 0.578, 1.023 3,2 201/202 A,S,F,T,K,Y,V,H,Q,M,I,R,L 47 K LYS47:A 2.133 1 2.136, 2.136 1,1 202/202 S,F,T,N,K,Y,E,V,Q,C,L,A,W,P,D,R 48 F PHE48:A -0.571 7 -0.719,-0.459 7,6 202/202 A,F,T,V,M,C,D,I,L 49 M MET49:A 1.760 1 1.023, 2.136 2,1 202/202 F,S,T,N,K,Y,E,V,Q,M,L,A,P,D,R,I,G 50 L LEU50:A -0.310 6 -0.459,-0.146 6,5 201/202 A,S,F,T,Y,V,M,I,L 51 G GLY51:A -1.404 9 -1.484,-1.315 9,9 186/202 H,N,D,R,K,G 52 K LYS52:A 0.309 4 0.045, 0.578 5,3 187/202 S,T,N,K,Y,E,V,Q,L,A,P,H,D,R,I,G 53 Q GLN53:A -0.242 6 -0.459,-0.146 6,5 201/202 S,T,N,K,E,H,Q,C,D,G,L 54 E GLU54:A 0.536 3 0.277, 0.578 4,3 201/202 S,T,N,K,Y,E,Q,M,L,A,W,H,D,I,R,G 55 V VAL55:A -1.180 9 -1.315,-1.067 9,8 202/202 A,F,T,V,M,C,I,L 56 I ILE56:A -1.376 9 -1.484,-1.315 9,9 202/202 C,I,P,L,V 57 R ARG57:A 0.525 3 0.277, 0.578 4,3 202/202 A,S,T,W,P,K,Y,E,V,Q,C,D,R,I,L 58 G GLY58:A -1.329 9 -1.484,-1.315 9,9 202/202 A,D,G,E 59 W TRP59:A -0.589 7 -0.719,-0.459 7,6 202/202 F,M,W,I,L,V 60 E GLU60:A -1.003 8 -1.067,-0.953 8,8 202/202 S,A,T,K,E,Q,D,R,I,L 61 E GLU61:A 0.496 3 0.277, 0.578 4,3 202/202 S,A,T,N,K,E,V,Q,M,D,I,R,L 62 G GLY62:A -0.765 7 -0.837,-0.719 8,7 202/202 A,S,Q,N,C,P,G,E 63 V VAL63:A -0.382 6 -0.459,-0.312 6,6 202/202 F,A,M,T,I,L,V 64 A ALA64:A 0.964 2 1.023, 1.023 2,2 202/202 S,A,T,K,P,E,V,H,Q,M,I,R,G,L 65 Q GLN65:A -0.607 7 -0.719,-0.459 7,6 202/202 S,A,T,N,P,K,Y,E,Q,D,R,G,L 66 M MET66:A -0.832 8 -0.953,-0.719 8,7 202/202 S,A,T,K,V,H,M,I,L 67 S SER67:A -0.401 6 -0.593,-0.312 7,6 202/202 S,A,T,N,P,K,E,H,Q,D,C,R,G,L 68 V VAL68:A 0.250 4 0.045, 0.277 5,4 202/202 S,A,T,N,K,P,E,V,M,R,I,L 69 G GLY69:A -1.258 9 -1.315,-1.186 9,9 202/202 S,D,N,K,G,E 70 Q GLN70:A -0.783 8 -0.837,-0.719 8,7 202/202 S,A,Q,T,D,G,E 71 R ARG71:A 0.004 5 -0.146, 0.045 5,5 202/202 A,S,T,N,K,E,V,H,Q,D,R,I,G,L 72 A ALA72:A -0.735 7 -0.837,-0.593 8,7 202/202 F,S,A,T,W,K,E,V,C,R,I,L 73 K LYS73:A 0.896 2 0.578, 1.023 3,2 202/202 A,F,T,N,K,E,V,H,Q,M,D,I,R,L 74 L LEU74:A -0.171 6 -0.312, 0.045 6,5 202/202 A,F,C,I,L,Y,V 75 T THR75:A 0.847 2 0.578, 1.023 3,2 202/202 S,F,A,T,N,P,K,E,Y,V,H,Q,D,R,I,L 76 I ILE76:A -0.878 8 -0.953,-0.837 8,8 202/202 F,A,T,V,M,C,I,L 77 S SER77:A -0.714 7 -0.837,-0.593 8,7 202/202 S,A,T,N,K,P,E,H,Q,D,G 78 P PRO78:A -0.511 7 -0.593,-0.312 7,6 202/202 F,A,S,Q,P,G,Y 79 D ASP79:A 0.247 4 0.045, 0.277 5,4 202/202 F,A,S,N,K,P,E,H,Q,D,R,G 80 Y TYR80:A -0.180 6 -0.312, 0.045 6,5 202/202 S,F,A,W,N,K,E,Y,V,Q,M,D,C,L 81 A ALA81:A -0.585 7 -0.719,-0.459 7,6 202/202 S,A,T,N,E,Q,C,D,G,L 82 Y TYR82:A -1.256 9 -1.315,-1.186 9,9 202/202 A,F,H,Y,V 83 G GLY83:A -0.846 8 -0.953,-0.719 8,7 200/202 H,Q,D,P,I,G 84 A ALA84:A 0.754 3 0.578, 1.023 3,2 201/202 A,S,T,N,P,K,E,V,H,Q,D,G 85 T THR85:A 0.871 2 0.578, 1.023 3,2 201/202 S,A,F,T,N,K,E,V,H,Q,M,D,R,I,G,L 86 G GLY86:A -0.230 6 -0.312,-0.146 6,5 201/202 A,S,T,N,K,P,E,H,Q,D,R,G 87 H HIS87:A 0.118 5 -0.146, 0.277 5,4 201/202 F,S,A,T,N,K,Y,V,H,Q,D,C,R,I,G,L 88 P PRO88:A 0.098 5 -0.146, 0.277 5,4 98/202 A,S,P,E,V,H,Q,I,G,L 89 G GLY89:A 0.768 3 0.578, 1.023 3,2 124/202 S,A,T,N,K,P,Y,E,Q,D,R,G 90 I ILE90:A 1.696 1 1.023, 2.136 2,1 130/202 S,F,T,K,E,Y,V,M,C,L,A,W,P,H,D,I,G 91 I ILE91:A -1.233 9 -1.315,-1.186 9,9 127/202 Q,P,I,L,V 92 P PRO92:A -1.062 8 -1.186,-0.953 9,8 134/202 A,S,Q,D,P,G,L,E 93 P PRO93:A -0.468 6 -0.593,-0.312 7,6 201/202 S,A,T,K,P,E,Q,R,G 94 H HIS94:A -0.734 7 -0.837,-0.593 8,7 201/202 F,A,S,N,K,E,Y,H,Q,D,R,G 95 A ALA95:A -0.805 8 -0.953,-0.719 8,7 202/202 S,A,Q,T,D,K,R,E 96 T THR96:A -0.104 5 -0.312, 0.045 6,5 202/202 S,A,T,K,P,E,V,H,Q,D,I,G,L 97 L LEU97:A -1.200 9 -1.315,-1.186 9,9 202/202 A,T,I,L,V 98 V VAL98:A 1.293 1 1.023, 2.136 2,1 202/202 S,F,T,N,K,Y,E,V,Q,M,C,L,H,D,R,I 99 F PHE99:A -1.252 9 -1.315,-1.186 9,9 202/202 F,W,I,Y,L,V 100 D ASP100:A 0.067 5 -0.146, 0.277 5,4 202/202 S,A,T,N,K,Y,E,V,H,Q,M,D,I 101 V VAL101:A -0.720 7 -0.837,-0.593 8,7 202/202 A,T,C,I,L,V 102 E GLU102:A -0.533 7 -0.719,-0.459 7,6 201/202 A,S,T,N,K,Y,E,V,H,D,R,L 103 L LEU103:A -0.783 8 -0.953,-0.719 8,7 201/202 A,F,M,I,Y,L,V 104 L LEU104:A 0.271 4 0.045, 0.578 5,3 200/202 S,F,T,N,K,Y,V,H,Q,M,I,R,L 105 K LYS105:A 0.860 2 0.578, 1.023 3,2 196/202 A,S,T,N,K,E,Q,D,R,G,L 106 L LEU106:A -0.216 6 -0.312,-0.146 6,5 187/202 A,F,T,W,V,M,I,L 107 E GLU107:A -0.492 7 -0.719,-0.312 7,6 118/202 Q,D,K,E *Below the confidence cut-off - The calculations for this site were performed on less than 6 non-gaped homologue sequences, or the confidence interval for the estimated score is equal to- or larger than- 4 color grades.