Amino Acid Conservation Scores =============================== - POS: The position of the AA in the SEQRES derived sequence. - SEQ: The SEQRES derived sequence in one letter code. - 3LATOM: The ATOM derived sequence in three letter code, including the AA's positions as they appear in the PDB file and the chain identifier. - SCORE: The normalized conservation scores. - COLOR: The color scale representing the conservation scores (9 - conserved, 1 - variable). - CONFIDENCE INTERVAL: When using the bayesian method for calculating rates, a confidence interval is assigned to each of the inferred evolutionary conservation scores. - CONFIDENCE INTERVAL COLORS: When using the bayesian method for calculating rates. The color scale representing the lower and upper bounds of the confidence interval. - MSA DATA: The number of aligned sequences having an amino acid (non-gapped) from the overall number of sequences at each position. - RESIDUE VARIETY: The residues variety at each position of the multiple sequence alignment. POS SEQ 3LATOM SCORE COLOR CONFIDENCE INTERVAL CONFIDENCE INTERVAL COLORS MSA DATA RESIDUE VARIETY (normalized) 1 E - 0.301 4 -0.285, 0.476 6,3 11/74 A,Q,D,N,E 2 N - 0.618 3 0.153, 0.969 4,2 15/74 A,Q,M,D,N,K,E 3 A - 1.543 1 0.969, 2.250 2,1 15/74 A,S,N,K,E,Q,M,D,L 4 L - 0.063 5 -0.450, 0.476 6,3 15/74 M,N,K,I,L 5 K - 0.216 4 -0.285, 0.476 6,3 19/74 A,S,Q,K,L,V 6 K - -1.147 9 -1.299,-1.034 9,8 20/74 K,E 7 S - 0.573 3 0.153, 0.969 4,2 20/74 A,S,T,C,I,K,G,L 8 D - -0.390 6 -0.719,-0.090 7,5 20/74 S,M,D,P,G 9 G - -0.076 5 -0.450, 0.153 6,4 21/74 A,S,T,M,N,K,G 10 T - 1.016 2 0.476, 2.250 3,1 22/74 S,A,T,K,V,H,R,G 11 R ARG420:A -0.035 5 -0.450, 0.153 6,4 24/74 R,K,G,L 12 K LYS421:A 0.145 5 -0.285, 0.476 6,3 24/74 H,S,Q,T,R,K,V 13 S SER422:A -0.082 5 -0.450, 0.153 6,4 24/74 S,Q,T,M,N,K,G,L,V 14 R ARG423:A -0.119 5 -0.450, 0.153 6,4 22/74 S,P,R,K,L 15 I ILE424:A -0.326 6 -0.592,-0.090 7,5 23/74 M,I,L,V 16 T THR425:A 0.528 3 0.153, 0.969 4,2 24/74 S,F,T,N,I,K,R,L 17 N ASN426:A 0.731 3 0.153, 0.969 4,2 24/74 S,A,N,D,G,V 18 Y TYR427:A -0.168 6 -0.450, 0.153 6,4 24/74 Q,C,I,E,L,Y,V 19 P PRO428:A 0.159 4 -0.285, 0.476 6,3 23/74 S,T,D,P,G,E,V 20 K LYS429:A -1.054 8 -1.213,-0.937 9,8 25/74 A,N,K 21 L LEU430:A -0.587 7 -0.833,-0.285 8,6 25/74 A,G,L,Y 22 E GLU431:A 0.163 4 -0.285, 0.476 6,3 25/74 T,D,K,Y,E,V 23 D ASP432:A -1.049 8 -1.213,-0.937 9,8 25/74 N,D,R 24 A ALA433:A -1.266 9 -1.388,-1.213 9,9 25/74 A,G 25 N ASN434:A -0.679 7 -0.833,-0.450 8,6 25/74 A,H,T,N,D,R,E 26 K LYS435:A 0.481 3 0.153, 0.969 4,2 25/74 S,W,T,D,N,K,E 27 A ALA436:A -1.066 8 -1.213,-0.937 9,8 25/74 S,A,Q,T 28 G GLY437:A -0.819 8 -1.034,-0.592 8,7 25/74 Q,R,G,V 29 T THR438:A 0.489 3 0.153, 0.969 4,2 26/74 S,T,R,P,G,E 30 K LYS439:A -0.432 6 -0.719,-0.285 7,6 26/74 D,R,K,G,L,E 31 E GLU440:A 0.781 2 0.476, 0.969 3,2 28/74 S,T,N,P,K,Y,E,H,D,R,G 32 G GLY441:A -0.138 5 -0.450, 0.153 6,4 28/74 A,S,Q,K,R,G 33 Y TYR442:A 1.841 1 0.969, 2.250 2,1 28/74 F,A,T,N,K,Y,E,H,Q,I,R,L 34 K LYS443:A 1.820 1 0.969, 2.250 2,1 28/74 T,N,K,E,V,H,Q,D,I,L 35 C CYS444:A -0.666 7 -0.937,-0.450 8,6 28/74 Q,T,C,N,R 36 T THR445:A -0.892 8 -1.034,-0.719 8,7 30/74 M,T,K,I,G,V 37 L LEU446:A -0.538 7 -0.833,-0.285 8,6 30/74 T,N,D,G,L,E 38 V VAL447:A -0.768 8 -0.937,-0.592 8,7 31/74 Q,N,I,K,E,L,V 39 L LEU448:A -0.216 6 -0.450, 0.153 6,4 32/74 A,M,D,P,I,L,V 40 T THR449:A -0.778 8 -0.937,-0.592 8,7 36/74 A,T,N,P,K,V,M,R 41 E GLU450:A -0.546 7 -0.719,-0.285 7,6 37/74 A,S,Q,T,K,E,V 42 G GLY451:A -0.331 6 -0.592,-0.090 7,5 42/74 S,Q,N,G,L,E,V 43 D ASP452:A -0.237 6 -0.450,-0.090 6,5 45/74 F,N,K,E,H,Q,D,I,L 44 S SER453:A -0.303 6 -0.450,-0.090 6,5 47/74 S,A,N,P,Y,E,V,D,I,L 45 A ALA454:A -0.217 6 -0.450,-0.090 6,5 52/74 A,S,T,N,K,E,Y,H,Q,D,G 46 L LEU455:A 0.387 4 0.153, 0.476 4,3 62/74 S,T,P,K,E,M,D,R,G,L 47 S SER456:A 0.467 3 0.153, 0.969 4,2 64/74 S,A,T,N,P,K,E,V,Q,R,I,G 48 L LEU457:A -0.272 6 -0.450,-0.090 6,5 69/74 S,F,A,I,L,V 49 A ALA458:A -1.090 9 -1.213,-0.937 9,8 24/74 A,C,L 50 V VAL459:A -0.181 6 -0.450, 0.153 6,4 24/74 Q,M,R,L,V 51 A ALA460:A -0.810 8 -1.034,-0.719 8,7 24/74 S,A,T,N 52 G GLY461:A -1.121 9 -1.299,-1.034 9,8 24/74 S,G 53 L LEU462:A -0.922 8 -1.126,-0.719 9,7 24/74 R,L 54 A ALA463:A -0.473 7 -0.719,-0.285 7,6 24/74 A,S,T,N,G,E 55 V VAL464:A -1.070 8 -1.213,-0.937 9,8 23/74 S,I,V 56 V VAL465:A -0.296 6 -0.592,-0.090 7,5 24/74 D,I,E,L,V 57 G GLY466:A -1.073 9 -1.299,-0.937 9,8 24/74 Q,G 58 R ARG467:A -0.864 8 -1.034,-0.719 8,7 24/74 N,P,R,K 59 D ASP468:A -0.646 7 -0.833,-0.450 8,6 24/74 N,D,R,K,E 60 Y TYR469:A 1.572 1 0.969, 2.250 2,1 24/74 S,F,T,K,Y,H,R,L 61 Y TYR470:A -0.486 7 -0.833,-0.285 8,6 24/74 F,T,C,Y 62 G GLY471:A -1.251 9 -1.388,-1.213 9,9 24/74 G 63 C CYS472:A -1.112 9 -1.213,-1.034 9,8 24/74 M,C,V 64 Y TYR473:A -0.897 8 -1.126,-0.719 9,7 24/74 F,I,Y 65 P PRO474:A -1.138 9 -1.299,-1.034 9,8 24/74 S,P 66 L LEU475:A -1.254 9 -1.388,-1.213 9,9 24/74 L 67 R ARG476:A -0.810 8 -1.034,-0.592 8,7 24/74 K,R,G,E 68 G GLY477:A -1.251 9 -1.388,-1.213 9,9 24/74 G 69 K LYS478:A -0.101 5 -0.285, 0.153 6,4 67/74 T,N,K,E,V,Q,I,R,L 70 M MET479:A 0.764 3 0.476, 0.969 3,2 71/74 A,S,N,K,P,E,Q,M,D,I,R,L 71 L LEU480:A -0.047 5 -0.285, 0.153 6,4 71/74 A,F,T,K,V,Q,M,R,I,L 72 N ASN481:A -0.569 7 -0.719,-0.450 7,6 71/74 A,S,N,P,E,D,R,G 73 V VAL482:A -0.868 8 -1.034,-0.719 8,7 72/74 A,F,I,L,V 74 R ARG483:A -0.334 6 -0.450,-0.090 6,5 72/74 S,A,T,K,E,H,Q,C,D,R,G 75 E GLU484:A 0.659 3 0.476, 0.969 3,2 72/74 S,A,Q,T,D,N,K,E 76 A ALA485:A -0.708 7 -0.937,-0.592 8,7 24/74 A,K,G,L,V 77 S SER486:A -0.601 7 -0.833,-0.450 8,6 24/74 A,S,T,D,N,R 78 A ALA487:A 1.672 1 0.969, 2.250 2,1 24/74 F,A,S,T,N,P,H,M,D,I,L 79 D ASP488:A -0.033 5 -0.450, 0.153 6,4 24/74 S,A,T,D,K,E 80 Q GLN489:A -0.968 8 -1.126,-0.833 9,8 24/74 Q,K,R 81 I ILE490:A -0.294 6 -0.592,-0.090 7,5 24/74 A,I,L,V 82 L LEU491:A 1.215 1 0.476, 2.250 3,1 24/74 A,S,M,T,R,K,L 83 K LYS492:A 0.008 5 -0.285, 0.153 6,4 24/74 S,T,D,N,K,E 84 N ASN493:A -1.230 9 -1.299,-1.126 9,9 24/74 C,N 85 A ALA494:A -0.199 6 -0.450, 0.153 6,4 24/74 A,Q,K,E,V 86 E GLU495:A -1.038 8 -1.213,-0.937 9,8 24/74 G,E,V 87 I ILE496:A -1.076 9 -1.213,-0.937 9,8 24/74 I,L,V 88 Q GLN497:A -0.565 7 -0.833,-0.285 8,6 24/74 S,Q,T,N,E 89 A ALA498:A -0.343 6 -0.592,-0.090 7,5 24/74 S,A,N,D,G,E 90 I ILE499:A -0.384 6 -0.719,-0.090 7,5 24/74 M,I,L 91 K LYS500:A 0.027 5 -0.285, 0.476 6,3 24/74 F,T,C,I,K,L,V 92 K LYS501:A -0.050 5 -0.450, 0.153 6,4 24/74 Q,T,N,C,K,R,L 93 I ILE502:A -0.900 8 -1.034,-0.719 8,7 24/74 F,A,S,I,V 94 M MET503:A -0.145 5 -0.450, 0.153 6,4 24/74 M,I,L,V 95 G GLY504:A -1.251 9 -1.388,-1.213 9,9 24/74 G 96 L LEU505:A -1.102 9 -1.299,-1.034 9,8 24/74 F,L 97 Q GLN506:A -0.656 7 -0.833,-0.450 8,6 72/74 S,A,F,T,K,E,V,Q,D,I 98 H HIS507:A 0.043 5 -0.090, 0.153 5,4 72/74 A,F,T,Y,V,H,Q,M,I,L 99 R ARG508:A 0.142 5 -0.090, 0.476 5,3 73/74 A,S,T,N,K,E,V,Q,D,R,G 100 K LYS509:A 0.616 3 0.476, 0.969 3,2 74/74 S,A,F,T,N,K,E,V,Q,M,C,D,R 101 K LYS510:A -0.278 6 -0.450,-0.090 6,5 74/74 S,A,T,N,K,E,V,H,C,D,I,R 102 Y TYR511:A -0.965 8 -1.126,-0.833 9,8 74/74 F,N,Y 103 E GLU512:A 1.035 2 0.476, 2.250 3,1 24/74 T,D,I,K,R,E 104 D ASP513:A -0.360 6 -0.592,-0.090 7,5 24/74 S,T,N,D,E 105 T THR514:A 0.650 3 0.153, 0.969 4,2 24/74 F,A,T,P,V,M,R,I,L 106 K LYS515:A -0.202 6 -0.592, 0.153 7,4 24/74 A,N,D,R,K,E 107 S SER516:A 0.038 5 -0.285, 0.476 6,3 24/74 S,T,D,K,G,E 108 L LEU517:A -0.617 7 -0.833,-0.450 8,6 74/74 S,M,I,G,L 109 R ARG518:A -0.705 7 -0.833,-0.592 8,7 74/74 S,A,N,K,E,D,R,L 110 Y TYR519:A -1.345 9 -1.388,-1.299 9,9 74/74 Y 111 G GLY520:A -0.933 8 -1.034,-0.833 8,8 74/74 S,A,Q,G 112 H HIS521:A -0.917 8 -1.034,-0.833 8,8 74/74 H,S,Q,M,C,R,K,L 113 L LEU522:A -0.849 8 -0.937,-0.719 8,7 74/74 S,M,I,L,Y,V 114 M MET523:A -1.179 9 -1.299,-1.126 9,9 74/74 M,T,I,L,V 115 I ILE524:A -1.143 9 -1.213,-1.034 9,8 74/74 A,I,L,V 116 M MET525:A -0.947 8 -1.034,-0.833 8,8 74/74 T,K,V,Q,M,C,I,L 117 T THR526:A -0.317 6 -0.450,-0.090 6,5 74/74 A,H,S,T,D,G,E,V 118 D ASP527:A -1.310 9 -1.388,-1.299 9,9 24/74 D 119 Q GLN528:A -1.311 9 -1.388,-1.299 9,9 24/74 Q 120 D ASP529:A -1.310 9 -1.388,-1.299 9,9 24/74 D 121 H HIS530:A -0.280 6 -0.592,-0.090 7,5 24/74 H,A,Q,Y,E,L,V 122 D ASP531:A -1.310 9 -1.388,-1.299 9,9 24/74 D 123 G GLY532:A -1.251 9 -1.388,-1.213 9,9 24/74 G 124 S SER533:A -1.166 9 -1.299,-1.126 9,9 24/74 S,C,Y 125 H HIS534:A -1.190 9 -1.299,-1.126 9,9 24/74 H,K 126 I ILE535:A -1.329 9 -1.388,-1.299 9,9 24/74 I 127 K LYS536:A -1.132 9 -1.299,-1.034 9,8 24/74 K,L 128 G GLY537:A -1.251 9 -1.388,-1.213 9,9 24/74 G 129 L LEU538:A -1.254 9 -1.388,-1.213 9,9 24/74 L 130 I ILE539:A -0.295 6 -0.592,-0.090 7,5 24/74 I,L,V 131 I ILE540:A -0.912 8 -1.126,-0.833 9,8 24/74 M,I,L,V 132 N ASN541:A -1.222 9 -1.299,-1.126 9,9 24/74 A,N 133 F PHE542:A -0.499 7 -0.833,-0.285 8,6 24/74 F,A,M,Y 134 L LEU543:A -0.766 8 -1.034,-0.592 8,7 24/74 F,I,L 135 E GLU544:A -0.948 8 -1.126,-0.833 9,8 24/74 H,Q,E 136 S SER545:A 0.566 3 0.153, 0.969 4,2 24/74 A,S,T,K,Y,H,C,L 137 S SER546:A -0.676 7 -0.937,-0.450 8,6 24/74 S,F,Q,N,L 138 F PHE547:A -0.401 6 -0.719,-0.090 7,5 24/74 F,W,Y 139 L LEU548:A -1.131 9 -1.299,-1.034 9,8 24/74 P,L 140 G GLY549:A -0.793 8 -1.034,-0.592 8,7 24/74 S,Q,N,K,G,E 141 L LEU550:A -1.254 9 -1.388,-1.213 9,9 24/74 L 142 L LEU551:A -0.607 7 -0.833,-0.450 8,6 24/74 I,L,V 143 D ASP552:A 1.196 1 0.476, 2.250 3,1 24/74 N,K,E,V,H,Q,D,I,R 144 I ILE553:A -0.272 6 -0.592,-0.090 7,5 23/74 T,N,Y,V,H,R,I,L 145 Q GLN554:A 1.180 1 0.476, 2.250 3,1 23/74 Q,N,D,K,R,P,G,E 146 G GLY555:A -0.878 8 -1.126,-0.719 9,7 17/74 S,G,E 147 F PHE556:A -1.089 9 -1.299,-0.937 9,8 24/74 F,Y 148 L LEU557:A -0.894 8 -1.126,-0.719 9,7 24/74 I,L,V 149 L LEU558:A 0.210 4 -0.285, 0.476 6,3 24/74 S,Q,I,K,E,L,V 150 E GLU559:A -0.496 7 -0.833,-0.285 8,6 24/74 S,Q,I,R,E,L 151 F PHE560:A -1.091 9 -1.299,-0.937 9,8 24/74 F,L 152 I ILE561:A -0.422 6 -0.719,-0.285 7,6 24/74 A,S,T,I,R,L,V 153 T THR562:A -1.334 9 -1.388,-1.299 9,9 24/74 T 154 P PRO563:A -1.268 9 -1.388,-1.213 9,9 24/74 P 155 I ILE564:A -0.935 8 -1.126,-0.833 9,8 24/74 I,L,V 156 I ILE565:A -0.430 6 -0.719,-0.285 7,6 24/74 I,L,V 157 K LYS566:A -1.055 8 -1.213,-0.937 9,8 24/74 K,R 158 V VAL567:A -0.392 6 -0.719,-0.090 7,5 24/74 A,C,I,V 159 S SER568:A -0.137 5 -0.450, 0.153 6,4 24/74 S,Q,W,T,R,K,Y 160 I ILE569:A -0.150 5 -0.450, 0.153 6,4 24/74 H,R,I,K,L,E,V 161 T THR570:A 1.422 1 0.969, 2.250 2,1 13/74 S,T,N,P,K,G 162 K LYS571:A 0.816 2 0.153, 2.250 4,1 11/74 A,N,D,K,G 163 P PRO572:A 0.479 3 -0.090, 0.969 5,2 10/74 P,R,K,G 164 T THR573:A 1.635 1 0.969, 2.250 2,1 23/74 A,S,T,N,P,K,D,I,G 165 K LYS574:A 0.202 4 -0.285, 0.476 6,3 23/74 S,H,T,N,D,K 166 N ASN575:A 1.018 2 0.476, 2.250 3,1 24/74 S,T,N,K,E,Q,M,R 167 T THR576:A -0.094 5 -0.450, 0.153 6,4 24/74 Q,T,I,K,P,E,V 168 I ILE577:A 1.836 1 0.969, 2.250 2,1 24/74 T,K,Y,V,H,Q,M,I,R,L 169 A ALA578:A -0.452 6 -0.719,-0.285 7,6 24/74 S,A,P,E 170 F PHE579:A -1.248 9 -1.388,-1.213 9,9 24/74 F 171 Y TYR580:A 0.122 5 -0.285, 0.476 6,3 24/74 F,H,T,Y 172 N ASN581:A -0.667 7 -0.833,-0.450 8,6 24/74 S,T,N,Y 173 M MET582:A 0.557 3 0.153, 0.969 4,2 24/74 F,M,I,P,L,E 174 P PRO583:A -0.352 6 -0.719,-0.090 7,5 24/74 A,Q,N,P,K,R 175 D ASP584:A -0.743 7 -0.937,-0.592 8,7 24/74 S,D,E 176 Y TYR585:A -0.399 6 -0.719,-0.090 7,5 24/74 F,Y 177 E GLU586:A -0.509 7 -0.833,-0.285 8,6 24/74 S,H,D,R,E 178 K LYS587:A 0.783 2 0.153, 0.969 4,2 24/74 H,A,Q,K,R,Y,E 179 W TRP588:A -1.117 9 -1.299,-1.034 9,8 24/74 W 180 R ARG589:A -0.383 6 -0.719,-0.090 7,5 24/74 A,Q,R,K 181 E GLU590:A 0.200 4 -0.090, 0.476 5,3 24/74 S,M,N,D,R,K,E 182 E GLU591:A 1.986 1 2.250, 2.250 1,1 24/74 S,A,T,N,K,E,V,H,D,R 183 E GLU592:A 0.889 2 0.476, 0.969 3,2 24/74 S,T,N,K,E,H,Q,M,L 184 S SER593:A 1.742 1 0.969, 2.250 2,1 24/74 S,A,T,N,P,E,Q,D,G 185 H HIS594:A -0.145 5 -0.450, 0.153 6,4 24/74 H,S,T,D,N,K,G,L 186 K LYS595:A 2.064 1 2.250, 2.250 1,1 24/74 S,A,W,T,K,Y,E,V,H,Q,G,L 187 F PHE596:A 1.747 1 0.969, 2.250 2,1 24/74 A,F,S,T,N,K,P,Y,V,H,C,R,G,L 188 T THR597:A 1.637 1 0.969, 2.250 2,1 18/74 A,S,T,N,R,K,G 189 W TRP598:A 0.155 4 -0.285, 0.476 6,3 24/74 H,W,Y 190 K LYS599:A -0.013 5 -0.450, 0.153 6,4 24/74 S,T,N,D,K,E 191 Q GLN600:A -0.463 7 -0.719,-0.285 7,6 24/74 H,A,Q,C,I,V 192 K LYS601:A -1.294 9 -1.388,-1.213 9,9 24/74 K 193 Y TYR602:A -1.240 9 -1.388,-1.126 9,9 24/74 Y 194 Y TYR603:A -1.078 9 -1.299,-0.937 9,8 24/74 F,Y 195 K LYS604:A -1.294 9 -1.388,-1.213 9,9 24/74 K 196 G GLY605:A -1.099 9 -1.299,-0.937 9,8 24/74 A,G 197 L LEU606:A -1.254 9 -1.388,-1.213 9,9 24/74 L 198 G GLY607:A -1.099 9 -1.299,-0.937 9,8 24/74 A,G 199 T THR608:A -1.259 9 -1.388,-1.213 9,9 24/74 A,T 200 S SER609:A -1.255 9 -1.388,-1.213 9,9 24/74 S,H 201 L LEU610:A -0.685 7 -0.937,-0.450 8,6 24/74 T,D,L 202 A ALA611:A 0.120 5 -0.285, 0.476 6,3 24/74 H,A,S,T,D,P,E 203 Q GLN612:A 1.093 1 0.476, 2.250 3,1 24/74 S,A,N,K,P,E,H,Q,M,D,R 204 E GLU613:A -1.067 8 -1.213,-0.937 9,8 24/74 D,E 205 V VAL614:A -0.206 6 -0.450, 0.153 6,4 24/74 F,A,M,I,G,V 206 R ARG615:A -0.455 6 -0.719,-0.285 7,6 24/74 Q,I,R,K 207 E GLU616:A -0.629 7 -0.937,-0.450 8,6 24/74 S,Q,I,E 208 Y TYR617:A -0.817 8 -1.034,-0.592 8,7 24/74 M,C,Y 209 F PHE618:A -1.248 9 -1.388,-1.213 9,9 24/74 F 210 S SER619:A -0.114 5 -0.450, 0.153 6,4 24/74 S,A,Q,T,R,K,L 211 N ASN620:A -0.440 6 -0.719,-0.285 7,6 24/74 A,H,N,D 212 L LEU621:A -0.710 7 -0.937,-0.592 8,7 24/74 F,M,I,L 213 D ASP622:A 0.030 5 -0.285, 0.476 6,3 24/74 A,N,D,K,G,E,V 214 R ARG623:A 0.093 5 -0.285, 0.476 6,3 24/74 H,T,D,N,R,K,L 215 H HIS624:A -0.936 8 -1.126,-0.833 9,8 24/74 H,M,N,K 216 L LEU625:A 0.815 2 0.153, 0.969 4,2 24/74 M,T,R,K,I,L,V 217 K LYS626:A -0.720 7 -0.937,-0.592 8,7 24/74 M,K,I,Y,V 218 I ILE627:A 2.064 1 2.250, 2.250 1,1 24/74 S,T,N,K,Y,E,Q,M,D,R,I,G,L 219 F PHE628:A -0.924 8 -1.126,-0.719 9,7 24/74 F,Y,L 220 H HIS629:A 1.054 2 0.476, 2.250 3,1 24/74 F,T,K,V,H,I,R,L 221 S SER630:A 0.151 5 -0.285, 0.476 6,3 19/74 A,S,T,W,Y 222 L LEU631:A 0.671 3 0.153, 0.969 4,2 23/74 S,A,T,N,E,V,M,D,L 223 Q GLN632:A -0.075 5 -0.450, 0.153 6,4 24/74 Q,D,K,G,E 224 G GLY633:A 0.871 2 0.476, 0.969 3,2 24/74 S,A,T,P,E,D,R,G 225 N - 2.185 1 2.250, 2.250 1,1 24/74 S,T,N,K,E,V,Q,D,R,I,G,L 226 D - -0.765 8 -0.937,-0.592 8,7 24/74 S,A,D,E 227 K - 0.181 4 -0.285, 0.476 6,3 24/74 A,S,H,D,K,G,E,V 228 D - 0.685 3 0.153, 0.969 4,2 24/74 A,N,K,E,H,Q,D,R 229 Y - 0.877 2 0.153, 0.969 4,2 24/74 H,S,A,Y,L 230 I - -0.870 8 -1.034,-0.719 8,7 24/74 F,M,I,L,V 231 D - 0.662 3 0.153, 0.969 4,2 24/74 S,H,T,D,K,R,E,V 232 L - -0.001 5 -0.285, 0.153 6,4 24/74 S,M,N,I,L 233 A - -1.091 9 -1.213,-0.937 9,8 24/74 A,Y,V 234 F - -1.248 9 -1.388,-1.213 9,9 24/74 F 235 S - -0.835 8 -1.034,-0.719 8,7 24/74 S,A,D,G 236 K - -0.615 7 -0.833,-0.450 8,6 24/74 S,A,K,R,G 237 K - -0.512 7 -0.833,-0.285 8,6 24/74 A,Q,D,K,G,E 238 K - 0.103 5 -0.285, 0.476 6,3 24/74 H,S,Q,R,K,G,L,E 239 A - 0.534 3 0.153, 0.969 4,2 24/74 A,S,I,E,V 240 D - -0.077 5 -0.450, 0.153 6,4 24/74 S,D,E,L 241 D - 1.646 1 0.969, 2.250 2,1 24/74 S,A,W,E,V,Q,D,R,G,L 242 R - -1.209 9 -1.299,-1.126 9,9 24/74 R,K 243 K - -1.052 8 -1.213,-0.937 9,8 24/74 Q,K,R 244 E - 1.017 2 0.476, 2.250 3,1 24/74 N,D,R,I,G,L,E,V 245 W - -0.495 7 -0.833,-0.285 8,6 24/74 W,N,L 246 L - -0.403 6 -0.719,-0.090 7,5 24/74 M,C,I,L,V 247 R - 0.070 5 -0.285, 0.476 6,3 24/74 S,Q,T,N,K,R 248 Q - 0.762 3 0.153, 0.969 4,2 24/74 S,A,T,N,K,E,H,Q,R,G 249 Y - 1.082 1 0.476, 2.250 3,1 24/74 H,S,F,W,T,Y,V 250 E - 1.319 1 0.476, 2.250 3,1 24/74 T,N,E,V,Q,M,D,I,R,L 251 P - 0.270 4 -0.090, 0.476 5,3 24/74 N,P,E,M,D,R,G,L 252 G - -0.281 6 -0.592,-0.090 7,5 24/74 S,D,G,E,L 253 T - 0.046 5 -0.285, 0.476 6,3 24/74 S,T,N,K,V,Q,I,R 254 V - 1.115 1 0.476, 2.250 3,1 24/74 F,T,K,Y,E,V,H,C,D,R,G 255 L - 0.677 3 0.153, 0.969 4,2 24/74 T,N,V,Q,M,D,I,R,L 256 D - -0.746 7 -0.937,-0.592 8,7 24/74 T,N,D,I,G 257 P - -0.097 5 -0.450, 0.153 6,4 24/74 H,Q,T,D,K,P,R,Y 258 T - 1.284 1 0.476, 2.250 3,1 24/74 A,S,T,K,E,Q,D,R,G 259 L - 0.422 4 -0.090, 0.969 5,2 24/74 A,Q,T,I,K,E,L,V 260 K - 0.891 2 0.476, 0.969 3,2 24/74 M,T,D,N,P,K,R 261 E - 1.991 1 2.250, 2.250 1,1 24/74 S,F,T,K,Y,E,H,Q,M,D,R,L 262 I - -0.627 7 -0.833,-0.450 8,6 24/74 I,L,V 263 P - -0.662 7 -0.833,-0.450 8,6 24/74 S,T,N,P 264 I - -0.457 6 -0.719,-0.285 7,6 24/74 F,C,I,Y,V 265 S - 1.130 1 0.476, 2.250 3,1 24/74 A,S,T,N,K,P,Y,Q,D,G 266 D - -0.749 7 -0.937,-0.592 8,7 24/74 D,E,L 267 F - -1.041 8 -1.213,-0.937 9,8 24/74 F,H 268 I - -0.593 7 -0.833,-0.450 8,6 24/74 I,L,V 269 N - -1.012 8 -1.126,-0.937 9,8 24/74 H,Q,N,D 270 K - -0.421 6 -0.719,-0.090 7,5 24/74 R,K,G,L,V 271 E - -1.068 8 -1.213,-0.937 9,8 24/74 Q,D,E 272 L - -0.759 7 -1.034,-0.592 8,7 24/74 F,M,T,L 273 I - -0.639 7 -0.833,-0.450 8,6 24/74 M,I,K,V 274 L LEU683:A -0.136 5 -0.450, 0.153 6,4 24/74 H,A,Q,T,Y,L 275 F PHE684:A -0.758 7 -1.034,-0.592 8,7 24/74 F,Y 276 S SER685:A -1.016 8 -1.126,-0.937 9,8 23/74 S,A,K,G 277 L LEU686:A -0.401 6 -0.719,-0.090 7,5 23/74 W,M,N,R,L,V 278 A ALA687:A 0.190 4 -0.285, 0.476 6,3 23/74 S,A,D,G,L,Y,V 279 D ASP688:A -0.883 8 -1.126,-0.719 9,7 23/74 A,D,G 280 N ASN689:A -0.548 7 -0.833,-0.285 8,6 23/74 T,N,I,L,V 281 I ILE690:A 0.826 2 0.153, 0.969 4,2 23/74 A,Q,I,K,L,E,V 282 R ARG691:A -1.372 9 -1.388,-1.388 9,9 73/74 R 283 S SER692:A -1.273 9 -1.299,-1.213 9,9 73/74 S,A,Q 284 I ILE693:A -1.104 9 -1.213,-1.034 9,8 73/74 I,L,V 285 P PRO694:A -1.309 9 -1.388,-1.299 9,9 73/74 A,P 286 N ASN695:A -0.850 8 -0.937,-0.719 8,7 73/74 S,F,H,C,N,D,E 287 V VAL696:A -0.300 6 -0.450,-0.090 6,5 73/74 F,S,A,M,C,I,L,V 288 L LEU697:A -0.860 8 -0.937,-0.719 8,7 73/74 S,M,I,R,G,L,V 289 D ASP698:A -1.372 9 -1.388,-1.388 9,9 73/74 D 290 G GLY699:A -1.348 9 -1.388,-1.299 9,9 73/74 G 291 F PHE700:A -0.779 8 -0.937,-0.592 8,7 73/74 F,Q,W,M,L 292 K LYS701:A -1.332 9 -1.388,-1.299 9,9 73/74 T,K 293 P PRO702:A -1.306 9 -1.388,-1.299 9,9 73/74 R,P 294 G GLY703:A -1.254 9 -1.299,-1.213 9,9 73/74 S,A,G,V 295 Q GLN704:A -1.164 9 -1.213,-1.126 9,9 74/74 S,H,Q,R 296 R ARG705:A -1.372 9 -1.388,-1.388 9,9 74/74 R 297 K LYS706:A -1.293 9 -1.388,-1.213 9,9 74/74 A,K,R 298 V VAL707:A -0.974 8 -1.034,-0.937 8,8 74/74 A,D,I,L,V 299 L LEU708:A -0.809 8 -0.937,-0.719 8,7 74/74 F,M,I,L,V 300 Y TYR709:A -0.148 5 -0.450, 0.153 6,4 74/74 A,H,F,W,Y 301 G GLY710:A -0.210 6 -0.450,-0.090 6,5 74/74 S,A,T,G,Y,V 302 C CYS711:A 0.689 3 0.476, 0.969 3,2 74/74 A,S,N,K,E,Q,M,C,D,I,G,L 303 F PHE712:A -0.462 7 -0.719,-0.285 7,6 74/74 F,S,N,K,V,M,R,I,G,L 304 K LYS713:A -0.271 6 -0.450,-0.090 6,5 74/74 A,F,N,K,E,Y,V,M,R,L 305 K LYS714:A 0.045 5 -0.090, 0.153 5,4 74/74 S,A,T,N,K,Y,E,H,D,R,L 306 N ASN715:A 0.106 5 -0.090, 0.476 5,3 74/74 S,F,A,W,N,K,P,Y,H,M,I,R 307 L LEU716:A 0.251 4 -0.090, 0.476 5,3 73/74 A,S,T,N,K,E,D,I,R,G,L 308 K LYS717:A 0.319 4 0.153, 0.476 4,3 74/74 S,A,T,N,R,K,G,Y,V 309 S SER718:A 0.709 3 0.476, 0.969 3,2 74/74 A,S,T,N,P,K,E,H,Q,R,G 310 E GLU719:A 0.153 4 -0.090, 0.476 5,3 74/74 S,A,F,T,P,E,Y,H,D 311 L LEU720:A 0.115 5 -0.090, 0.476 5,3 74/74 S,A,T,K,Y,V,M,C,R,I,L 312 K LYS721:A -1.367 9 -1.388,-1.388 9,9 74/74 K 313 V VAL722:A -1.020 8 -1.126,-0.937 9,8 74/74 A,S,C,G,V 314 A ALA723:A -1.116 9 -1.213,-1.034 9,8 74/74 S,F,A,G,V 315 Q GLN724:A -0.988 8 -1.126,-0.937 9,8 74/74 Q,N,D,K,R,E 316 L LEU725:A -0.564 7 -0.719,-0.450 7,6 74/74 F,S,A,W,T,I,L,V 317 A ALA726:A -0.938 8 -1.034,-0.833 8,8 74/74 A,S,T,I,G,V 318 P PRO727:A -1.220 9 -1.299,-1.126 9,9 74/74 A,P,G 319 Y TYR728:A -0.348 6 -0.592,-0.090 7,5 74/74 S,F,A,N,Y,E,H,D 320 V VAL729:A -1.073 9 -1.126,-1.034 9,8 74/74 T,I,V 321 S SER730:A -0.954 8 -1.126,-0.833 9,8 24/74 S,A 322 E GLU731:A -0.060 5 -0.450, 0.153 6,4 24/74 S,H,N,D,G,L,E 323 C CYS732:A 0.210 4 -0.090, 0.476 5,3 74/74 A,T,N,E,Y,V,H,Q,M,C,I,R,L 324 T THR733:A -0.919 8 -1.034,-0.833 8,8 74/74 S,Q,T,M,G 325 A ALA734:A -0.720 7 -0.833,-0.592 8,7 74/74 A,F,S,Q,N,K,G 326 Y TYR735:A -0.751 7 -0.937,-0.592 8,7 74/74 F,Y 327 H HIS736:A -1.281 9 -1.388,-1.213 9,9 74/74 H,Q,P 328 H HIS737:A -1.376 9 -1.388,-1.388 9,9 74/74 H 329 G GLY738:A -1.296 9 -1.388,-1.213 9,9 74/74 S,G 330 E GLU739:A -1.276 9 -1.299,-1.213 9,9 74/74 D,E 331 Q GLN740:A 0.478 3 0.153, 0.969 4,2 74/74 F,A,S,T,N,E,V,Q,M,G,L 332 S SER741:A -0.973 8 -1.034,-0.937 8,8 74/74 A,S,P 333 L LEU742:A -0.729 7 -0.833,-0.592 8,7 74/74 A,M,C,I,L,V 334 A ALA743:A -0.446 6 -0.592,-0.285 7,6 74/74 A,S,Q,M,N,E,Y,V 335 Q GLN744:A -0.300 6 -0.450,-0.090 6,5 74/74 S,T,E,Q,M,D,R,G 336 T THR745:A -0.809 8 -0.937,-0.719 8,7 74/74 S,A,T 337 I ILE746:A -0.975 8 -1.126,-0.833 9,8 74/74 M,I,L 338 I ILE747:A -0.959 8 -1.034,-0.833 8,8 74/74 S,I,V 339 G GLY748:A -1.010 8 -1.126,-0.937 9,8 74/74 N,K,R,G,L 340 L LEU749:A -0.807 8 -0.937,-0.719 8,7 74/74 A,M,L 341 A ALA750:A -1.242 9 -1.299,-1.213 9,9 74/74 S,A,G,V 342 Q GLN751:A -1.349 9 -1.388,-1.299 9,9 74/74 H,Q 343 N ASN752:A -0.026 5 -0.285, 0.153 6,4 74/74 A,S,T,W,N,K,P,Y,H,D 344 F PHE753:A -0.732 7 -0.937,-0.592 8,7 74/74 F,W,Y 345 V VAL754:A -0.946 8 -1.126,-0.833 9,8 24/74 T,C,P,V 346 G GLY755:A -1.251 9 -1.388,-1.213 9,9 24/74 G 347 S SER756:A -1.025 8 -1.126,-0.937 9,8 74/74 A,S,T,N,K,G 348 N ASN757:A -0.337 6 -0.592,-0.090 7,5 74/74 S,Q,M,N,Y,L,V 349 N ASN758:A -1.253 9 -1.299,-1.213 9,9 74/74 H,N,R 350 I ILE759:A 0.263 4 -0.090, 0.476 5,3 74/74 S,W,N,E,Y,V,H,M,C,I,L 351 Y TYR760:A -0.426 6 -0.592,-0.285 7,6 74/74 T,N,P,Y,E,V,M,I,L 352 L LEU761:A -0.597 7 -0.833,-0.450 8,6 74/74 F,T,C,L,V 353 L LEU762:A -0.693 7 -0.833,-0.592 8,7 74/74 F,I,L,V 354 L LEU763:A 0.331 4 0.153, 0.476 4,3 74/74 A,S,T,K,E,V,H,Q,M,D,I,R,L 355 P PRO764:A -0.970 8 -1.126,-0.833 9,8 74/74 S,M,P,I,G 356 N ASN765:A -0.471 7 -0.592,-0.285 7,6 74/74 S,N,E,H,Q,C,R,I,L 357 G GLY766:A -1.349 9 -1.388,-1.299 9,9 74/74 G 358 A ALA767:A -1.087 9 -1.213,-1.034 9,8 74/74 A,S,Q,M,N,L 359 F PHE768:A -1.226 9 -1.299,-1.126 9,9 74/74 F,W,N 360 G GLY769:A -1.349 9 -1.388,-1.299 9,9 74/74 G 361 T THR770:A -1.116 9 -1.213,-1.034 9,8 74/74 A,S,T,N 362 R ARG771:A -1.208 9 -1.299,-1.126 9,9 24/74 C,R 363 A ALA772:A -0.254 6 -0.592,-0.090 7,5 27/74 S,A,H,Q,T,N,K,P,L 364 T THR773:A 0.329 4 0.153, 0.476 4,3 74/74 S,A,T,P,E,V,H,Q,M,D,R,I,L 365 G GLY774:A -1.195 9 -1.299,-1.126 9,9 74/74 D,G,L 366 G GLY775:A -0.947 8 -1.034,-0.833 8,8 74/74 A,N,R,P,G 367 K LYS776:A -1.002 8 -1.126,-0.937 9,8 74/74 A,S,N,D,K,L 368 D ASP777:A -0.420 6 -0.592,-0.285 7,6 74/74 A,S,D,N,R,P,G 369 A ALA778:A -0.339 6 -0.450,-0.090 6,5 74/74 S,H,F,A,C,P 370 A ALA779:A -1.239 9 -1.299,-1.213 9,9 74/74 S,A,G 371 A ALA780:A -1.208 9 -1.299,-1.126 9,9 74/74 S,A,Q 372 A ALA781:A -0.780 8 -0.937,-0.719 8,7 74/74 S,A,Q,M,P,Y,V 373 R ARG782:A -1.372 9 -1.388,-1.388 9,9 74/74 R 374 Y TYR783:A -1.345 9 -1.388,-1.299 9,9 74/74 Y 375 I ILE784:A -1.289 9 -1.388,-1.213 9,9 74/74 T,I,L 376 Y TYR785:A -0.836 8 -0.937,-0.719 8,7 74/74 H,F,S,N,Y,E 377 T THR786:A -0.806 8 -0.937,-0.719 8,7 74/74 S,A,T,C,I,V 378 E GLU787:A -0.338 6 -0.450,-0.090 6,5 74/74 A,N,K,E,Q,M,R,I,L 379 L LEU788:A -0.966 8 -1.126,-0.833 9,8 74/74 M,I,L 380 N ASN789:A -0.193 6 -0.450,-0.090 6,5 73/74 A,S,W,T,N,E,Q,D,R 381 K LYS790:A 0.337 4 0.153, 0.476 4,3 74/74 S,A,K,P,E,Q,D,R,L 382 L LEU791:A 0.424 4 0.153, 0.476 4,3 74/74 S,F,A,T,Y,V,I,L 383 T THR792:A -0.128 5 -0.285, 0.153 6,4 74/74 S,A,T,C,I,G 384 R ARG793:A 0.321 4 0.153, 0.476 4,3 74/74 S,F,A,N,K,Y,E,V,H,Q,M,C,R,G,L 385 K LYS794:A 1.168 1 0.969, 0.969 2,2 74/74 A,F,S,T,K,Y,E,V,M,C,R,I,L 386 I ILE795:A -0.064 5 -0.285, 0.153 6,4 74/74 F,M,I,L,V 387 F PHE796:A -0.486 7 -0.719,-0.285 7,6 74/74 F,M,I,Y,L,V 388 H HIS797:A 0.671 3 0.476, 0.969 3,2 74/74 A,S,T,N,P,K,E,H,Q,I,R,L 389 P PRO798:A -0.244 6 -0.450,-0.090 6,5 74/74 S,A,N,K,P,Y,E,Q,D,G 390 A ALA799:A -0.384 6 -0.592,-0.285 7,6 74/74 A,N,K,Y,E,V,H,D,I,L 391 D ASP800:A -0.482 7 -0.592,-0.285 7,6 74/74 S,T,D,N,K,G,E 392 D ASP801:A -0.668 7 -0.833,-0.592 8,7 74/74 F,S,A,Q,D,K,E 393 P PRO802:A 1.158 1 0.969, 0.969 2,2 74/74 A,W,N,P,K,E,H,Q,D,G,L 394 L LEU803:A -0.868 8 -1.034,-0.719 8,7 74/74 A,Q,T,I,L,V 395 Y TYR804:A -1.084 9 -1.213,-1.034 9,8 74/74 F,A,I,Y,L,V 396 K LYS805:A 0.536 3 0.153, 0.969 4,2 74/74 S,T,N,K,P,E,V,Q,D,R 397 Y TYR806:A -0.376 6 -0.592,-0.285 7,6 74/74 H,F,M,W,K,Y 398 I ILE807:A 1.708 1 0.969, 2.250 2,1 74/74 S,F,A,T,N,K,E,V,Q,M,R,I,G,L 399 Q GLN808:A 0.953 2 0.476, 0.969 3,2 74/74 F,A,S,T,W,N,P,Y,E,V,Q,D,I,G 400 E GLU809:A -1.074 9 -1.126,-1.034 9,8 74/74 T,D,N,E 401 D ASP810:A -1.063 8 -1.126,-0.937 9,8 74/74 N,D,E 402 E GLU811:A -0.237 6 -0.450,-0.090 6,5 74/74 A,N,D,G,E 403 K LYS812:A -0.308 6 -0.450,-0.090 6,5 74/74 S,A,T,N,K,E,Q,M,C,R 404 T THR813:A 0.507 3 0.153, 0.969 4,2 74/74 S,F,W,T,K,E,V,Q,M,D,R,L 405 V VAL814:A 0.689 3 0.476, 0.969 3,2 74/74 S,A,K,Y,E,V,H,Q,M,D,I,R,L 406 E GLU815:A -1.293 9 -1.388,-1.213 9,9 74/74 Q,I,E 407 P PRO816:A -1.312 9 -1.388,-1.299 9,9 74/74 Q,P 408 E GLU817:A 1.101 1 0.969, 0.969 2,2 74/74 S,A,T,N,K,E,V,H,Q,M,D,I,L 409 W TRP818:A -0.272 6 -0.450,-0.090 6,5 73/74 A,W,Y,V,H,M,I,L 410 Y TYR819:A -0.806 8 -0.937,-0.719 8,7 74/74 M,Y,L,V 411 L LEU820:A -0.675 7 -0.833,-0.592 8,7 74/74 A,M,C,I,P,L,V 412 P PRO821:A -0.597 7 -0.719,-0.450 7,6 74/74 S,A,T,P,G 413 I ILE822:A -0.243 6 -0.450,-0.090 6,5 74/74 A,S,K,V,Q,M,R,I,G,L 414 L LEU823:A -0.259 6 -0.450,-0.090 6,5 74/74 F,I,L,V 415 P PRO824:A -1.356 9 -1.388,-1.299 9,9 74/74 P 416 M MET825:A -0.501 7 -0.592,-0.285 7,6 74/74 A,S,F,T,N,H,Q,M,L 417 I ILE826:A -0.660 7 -0.833,-0.450 8,6 74/74 A,I,L,V 418 L LEU827:A -1.153 9 -1.213,-1.034 9,8 74/74 F,I,L 419 V VAL828:A -0.247 6 -0.450,-0.090 6,5 74/74 A,M,T,C,I,L,V 420 N ASN829:A -1.358 9 -1.388,-1.299 9,9 74/74 N,E 421 G GLY830:A -1.279 9 -1.388,-1.213 9,9 74/74 G,Y 422 A ALA831:A -0.554 7 -0.719,-0.450 7,6 74/74 S,A,T,C,G,V 423 E GLU832:A -0.519 7 -0.719,-0.450 7,6 74/74 F,A,S,T,N,E,V,Q,D,G 424 G GLY833:A -1.291 9 -1.388,-1.213 9,9 74/74 N,G 425 I ILE834:A -1.354 9 -1.388,-1.299 9,9 74/74 P,I 426 G GLY835:A -1.247 9 -1.299,-1.213 9,9 74/74 S,A,G 427 T THR836:A -1.126 9 -1.213,-1.034 9,8 74/74 F,S,A,T,E,V 428 G GLY837:A -1.349 9 -1.388,-1.299 9,9 74/74 G 429 W TRP838:A -0.929 8 -1.034,-0.833 8,8 74/74 F,W,M,L,Y 430 S SER839:A -1.144 9 -1.213,-1.126 9,9 74/74 S,A,T,K 431 T THR840:A -1.120 9 -1.213,-1.034 9,8 74/74 S,W,T,C,Y 432 Y TYR841:A -0.439 6 -0.592,-0.285 7,6 74/74 F,S,T,N,K,Y,E,D 433 I ILE842:A -1.164 9 -1.213,-1.126 9,9 74/74 T,M,I,L,V 434 P PRO843:A -0.925 8 -1.034,-0.833 8,8 74/74 S,A,W,P,Y 435 P PRO844:A -0.800 8 -0.937,-0.719 8,7 74/74 A,S,N,P,L 436 F PHE845:A -0.906 8 -1.034,-0.833 8,8 74/74 F,H,C,R,Y 437 N ASN846:A -1.113 9 -1.213,-1.034 9,8 74/74 S,H,Q,D,N,R 438 P PRO847:A -0.402 6 -0.592,-0.285 7,6 74/74 A,T,P,Y,V,M,I,R,L 439 L LEU848:A 1.419 1 0.969, 2.250 2,1 74/74 A,S,T,N,K,E,V,H,D,I,R,G,L 440 E GLU849:A -1.086 9 -1.213,-1.034 9,8 74/74 D,E 441 I ILE850:A -0.139 5 -0.285, 0.153 6,4 74/74 S,T,I,L,V 442 I ILE851:A -0.085 5 -0.285, 0.153 6,4 74/74 S,A,T,V,M,C,I,G,L 443 K LYS852:A 0.369 4 0.153, 0.476 4,3 74/74 A,S,Q,T,N,D,K,G,E 444 N ASN853:A -0.544 7 -0.719,-0.450 7,6 74/74 S,A,Q,M,N,G,L,V 445 I ILE854:A 0.285 4 0.153, 0.476 4,3 74/74 A,T,C,R,I,L,V 446 R ARG855:A 0.486 3 0.153, 0.969 4,2 74/74 F,S,T,K,Y,V,Q,M,C,R,I,L 447 H HIS856:A 1.559 1 0.969, 2.250 2,1 74/74 S,A,W,K,Y,V,H,M,C,R,G,L 448 L LEU857:A 1.329 1 0.969, 2.250 2,1 74/74 F,A,K,Y,V,M,C,R,L 449 M MET858:A -0.035 5 -0.285, 0.153 6,4 74/74 S,A,M,I,L,V 450 N ASN859:A 0.323 4 0.153, 0.476 4,3 74/74 A,S,T,N,K,E,V,H,Q,D,R 451 D ASP860:A -0.071 5 -0.285, 0.153 6,4 74/74 S,N,K,E,H,Q,M,D,G 452 E GLU861:A 0.202 4 -0.090, 0.476 5,3 74/74 N,K,P,Y,E,H,Q,D,I,G,L 453 E GLU862:A 2.194 1 2.250, 2.250 1,1 74/74 A,S,T,N,P,K,E,V,Q,D,R,G 454 L LEU863:A 0.660 3 0.476, 0.969 3,2 68/74 A,T,P,V,M,C,I,L 455 E GLU864:A 0.678 3 0.476, 0.969 3,2 68/74 S,T,K,E,V,H,Q,D,G,L 456 Q GLN865:A 1.879 1 0.969, 2.250 2,1 68/74 S,F,T,P,K,Y,E,V,H,Q,D,I,L 457 M MET866:A -0.242 6 -0.450,-0.090 6,5 74/74 T,N,K,P,E,Q,M,I,L 458 H HIS867:A -0.158 6 -0.450, 0.153 6,4 74/74 H,A,Q,T,D,I,P,K,G,L,V 459 P PRO868:A -1.310 9 -1.388,-1.299 9,9 74/74 H,P 460 W TRP869:A -1.004 8 -1.126,-0.937 9,8 74/74 S,F,W,N,D,K 461 F PHE870:A -0.731 7 -0.937,-0.592 8,7 74/74 A,F,I,Y 462 R ARG871:A 1.236 1 0.969, 2.250 2,1 74/74 S,A,T,N,K,Y,E,V,Q,D,I,R,G,L 463 G GLY872:A -0.205 6 -0.450,-0.090 6,5 74/74 S,A,N,E,H,Q,D,G 464 W TRP873:A -0.463 7 -0.592,-0.285 7,6 74/74 F,S,W,T,Y,E,V,D,I,L 465 T THR874:A 1.593 1 0.969, 2.250 2,1 74/74 A,S,T,N,K,E,V,H,Q,M,I,R,G,L 466 G GLY875:A -0.776 8 -1.034,-0.592 8,7 30/74 A,Q,N,R,G 467 T THR876:A 0.829 2 0.476, 0.969 3,2 74/74 S,A,T,N,K,E,H,Q,D,R 468 I ILE877:A -0.371 6 -0.592,-0.285 7,6 74/74 S,A,T,Y,V,M,I,G,L 469 E GLU878:A -0.461 7 -0.719,-0.285 7,6 74/74 S,F,T,K,E,Y,Q,D,R,I 470 E GLU879:A 1.009 2 0.969, 0.969 2,2 74/74 S,A,T,N,P,K,Y,E,V,Q,D,R,G,L 471 I ILE880:A -0.411 6 -0.592,-0.285 7,6 74/74 F,S,A,T,N,E,V,Q,M,D,I,G,L 472 E GLU881:A -0.524 7 -0.719,-0.285 7,6 74/74 A,S,T,P,E,D,R,G 473 P PRO882:A -0.146 5 -0.285, 0.153 6,4 74/74 S,P,K,E,H,Q,D,R,G 474 L LEU883:A -0.145 5 -0.285, 0.153 6,4 74/74 S,A,T,N,K,E,Y,Q,D,G,L 475 R ARG884:A 0.014 5 -0.285, 0.153 6,4 71/74 S,N,K,E,Q,C,R,I,G,L 476 Y TYR885:A -0.194 6 -0.450,-0.090 6,5 74/74 F,I,Y,V 477 R ARG886:A 0.890 2 0.476, 0.969 3,2 74/74 A,S,T,P,K,E,Y,V,Q,R,I 478 M MET887:A 0.469 3 0.153, 0.969 4,2 74/74 F,A,S,T,V,Q,M,C,I,L 479 Y TYR888:A -0.495 7 -0.592,-0.285 7,6 74/74 S,A,T,N,K,Y,V,Q,C,I,R,L 480 G GLY889:A -0.603 7 -0.719,-0.450 7,6 74/74 S,A,G 481 R ARG890:A 0.599 3 0.476, 0.969 3,2 74/74 S,T,N,K,E,V,Q,R,I,L 482 I ILE891:A 0.729 3 0.476, 0.969 3,2 74/74 S,F,A,T,W,N,I,Y,V 483 E GLU892:A 1.680 1 0.969, 2.250 2,1 74/74 F,S,A,T,N,K,E,V,H,Q,D,I,R 484 Q GLN893:A -0.181 6 -0.450,-0.090 6,5 74/74 A,T,K,Y,E,V,Q,I,L 485 I ILE894:A -0.609 7 -0.719,-0.450 7,6 74/74 S,T,N,Y,E,V,H,C,I,L 486 G GLY895:A 2.199 1 2.250, 2.250 1,1 74/74 S,A,T,N,P,K,E,V,Q,D,R,I,G,L 487 D ASP896:A 2.247 1 2.250, 2.250 1,1 74/74 S,T,N,K,E,V,Q,M,L,A,P,H,D,R,I,G 488 N ASN897:A 2.130 1 2.250, 2.250 1,1 73/74 F,S,A,T,N,P,K,E,H,Q,D,R,G,L 489 V VAL898:A 0.678 3 0.476, 0.969 3,2 69/74 S,T,N,P,K,E,Y,V,H,Q,R,G 490 L LEU899:A -0.573 7 -0.719,-0.450 7,6 74/74 F,I,L,V 491 E GLU900:A -0.306 6 -0.450,-0.090 6,5 74/74 H,T,R,I,E,V 492 I ILE901:A -0.655 7 -0.833,-0.592 8,7 74/74 F,I,L,V 493 T THR902:A -0.721 7 -0.833,-0.592 8,7 74/74 S,T,N,K,Y,V,H,Q,D,I 494 E GLU903:A -1.183 9 -1.299,-1.126 9,9 74/74 A,Q,D,E 495 L LEU904:A -0.489 7 -0.719,-0.285 7,6 74/74 F,M,I,L,V 496 P PRO905:A -1.356 9 -1.388,-1.299 9,9 74/74 P 497 A ALA906:A -0.359 6 -0.592,-0.090 7,5 74/74 A,F,W,P,Y,V,H,I,L 498 R ARG907:A -0.372 6 -0.592,-0.285 7,6 74/74 T,N,K,E,Q,M,R,G 499 T THR908:A -0.188 6 -0.450,-0.090 6,5 74/74 F,S,A,T,K,V,Q,C,I,R,L 500 W TRP909:A -0.961 8 -1.034,-0.833 8,8 74/74 S,Q,W,N,P,L,V 501 T THR910:A -0.887 8 -1.034,-0.833 8,8 74/74 H,S,T,N,I,K,P,G,V 502 S SER911:A -0.365 6 -0.592,-0.285 7,6 74/74 S,A,T,N,E,V,H,Q,D 503 T THR912:A 0.441 4 0.153, 0.476 4,3 74/74 A,S,T,N,K,E,V,M,D,R,G 504 I ILE913:A -0.340 6 -0.592,-0.090 7,5 74/74 F,M,W,I,Y,L,V 505 K LYS914:A -0.579 7 -0.719,-0.450 7,6 74/74 H,A,K,R,I,L,V 506 E GLU915:A -0.233 6 -0.450,-0.090 6,5 74/74 S,A,T,N,K,E,Q,M,D,L 507 Y TYR916:A 0.598 3 0.476, 0.969 3,2 74/74 F,S,N,K,Y,E,V,H,Q,R,G 508 L LEU917:A -1.220 9 -1.299,-1.126 9,9 74/74 M,I,L,V 509 L LEU918:A -0.492 7 -0.592,-0.285 7,6 74/74 S,A,N,K,E,V,Q,D,G,L 510 L LEU919:A 0.666 3 0.476, 0.969 3,2 74/74 S,A,N,K,Y,E,V,D,R,I,G,L 511 G GLY920:A -0.197 6 -0.450,-0.090 6,5 74/74 S,F,N,P,V,Q,M,I,G,L 512 L LEU921:A -0.192 6 -0.450,-0.090 6,5 74/74 F,S,A,T,K,V,M,I,R,L 513 S SER922:A 1.518 1 0.969, 2.250 2,1 73/74 A,S,F,T,N,K,E,V,Q,M,D,R,I,G,L 514 G GLY923:A 0.638 3 -0.090, 0.969 5,2 13/74 A,N,G,E 515 N ASN924:A 0.842 2 0.153, 2.250 4,1 11/74 A,S,T,N,G 516 D ASP925:A 0.496 3 0.153, 0.969 4,2 67/74 A,Q,T,D,N,P,E 517 K LYS926:A -0.203 6 -0.450,-0.090 6,5 67/74 D,N,R,K,G,E,V 518 I ILE927:A 0.627 3 0.476, 0.969 3,2 68/74 T,K,P,E,V,Q,I,R,G 519 K LYS928:A 0.564 3 0.476, 0.969 3,2 74/74 A,S,T,P,K,V,H,Q,M,D,R,I,L 520 P PRO929:A 1.007 2 0.476, 0.969 3,2 74/74 A,S,Q,T,D,K,P,G,L,E,V 521 W TRP930:A 0.086 5 -0.090, 0.476 5,3 74/74 S,F,A,W,P,E,V,M,I,G,L 522 I ILE931:A -1.030 8 -1.126,-0.937 9,8 74/74 F,I,L,V 523 K LYS932:A 0.438 4 0.153, 0.476 4,3 74/74 S,A,T,N,K,E,V,Q,D,R,L 524 D ASP933:A -0.216 6 -0.450,-0.090 6,5 74/74 A,S,T,N,D,R,E 525 M MET934:A -0.277 6 -0.450,-0.090 6,5 74/74 F,M,I,Y,L,V 526 E GLU935:A -0.534 7 -0.719,-0.450 7,6 74/74 S,A,T,N,K,E,Q,R,I 527 E GLU936:A -1.079 9 -1.213,-1.034 9,8 74/74 A,S,Q,D,E 528 Q GLN937:A -0.530 7 -0.719,-0.450 7,6 74/74 S,N,Y,E,H,Q,D,R,L 529 H HIS938:A -0.830 8 -0.937,-0.719 8,7 74/74 H,A,S,T,N,C,G 530 D ASP939:A -0.356 6 -0.592,-0.285 7,6 74/74 S,A,T,N,D,G 531 D ASP940:A 1.057 2 0.969, 0.969 2,2 74/74 A,S,T,N,K,E,V,H,D,I,R,G 532 N ASN941:A -0.261 6 -0.450,-0.090 6,5 74/74 S,A,T,N,K,P,H,D,I,R,G 533 I ILE942:A -0.237 6 -0.450,-0.090 6,5 74/74 Q,M,T,C,I,L,V 534 K LYS943:A -0.828 8 -0.937,-0.719 8,7 74/74 S,H,C,D,K,R,E 535 F PHE944:A -0.554 7 -0.719,-0.450 7,6 74/74 F,I,L,V 536 I ILE945:A -0.556 7 -0.719,-0.450 7,6 74/74 F,A,T,N,E,Y,V,D,I,R,L 537 I ILE946:A -0.634 7 -0.719,-0.450 7,6 74/74 F,I,L,V 538 T THR947:A -0.067 5 -0.285, 0.153 6,4 74/74 S,T,N,K,E,V,Q,D,R,I,L 539 L LEU948:A 0.106 5 -0.090, 0.476 5,3 74/74 F,T,P,V,H,M,I,L 540 S SER949:A 0.031 5 -0.090, 0.153 5,4 74/74 S,A,T,N,P,K,H,D,R,L 541 P PRO950:A 0.352 4 0.153, 0.476 4,3 74/74 S,Q,D,N,P,K,R,E 542 E GLU951:A 0.151 5 -0.090, 0.476 5,3 74/74 A,F,S,N,K,E,D,R,G 543 E GLU952:A 0.197 4 -0.090, 0.476 5,3 74/74 S,F,A,T,N,K,E,V,H,Q,C,I,G,L 544 M MET953:A 0.519 3 0.153, 0.969 4,2 74/74 F,S,N,K,P,Y,E,V,M,D,I,L 545 A ALA954:A 0.888 2 0.476, 0.969 3,2 74/74 S,A,T,N,K,P,E,V,Q,M,D,R,G,L 546 K LYS955:A 0.595 3 0.476, 0.969 3,2 74/74 S,A,T,N,K,E,H,Q,D,R 547 T THR956:A 0.552 3 0.153, 0.969 4,2 74/74 F,S,A,W,T,K,Y,E,V,Q,M,I,G,L 548 R ARG957:A -0.114 5 -0.285, 0.153 6,4 74/74 A,F,E,V,H,I,R,L 549 K LYS958:A -0.014 5 -0.285, 0.153 6,4 70/74 A,N,K,E,Q,M,D,I,R,L 550 I ILE959:A -0.495 7 -0.719,-0.285 7,6 70/74 S,A,T,N,K,E,V,Q,M,D,I,G,L 551 G GLY960:A 0.011 5 -0.285, 0.153 6,4 74/74 F,S,T,N,K,E,Y,H,Q,D,G,L 552 F PHE961:A -0.847 8 -1.034,-0.719 8,7 74/74 F,C,I,L 553 Y TYR962:A 0.415 4 0.153, 0.476 4,3 74/74 F,E,Y,H,M,D,I,L 554 E GLU963:A -0.240 6 -0.450,-0.090 6,5 74/74 S,A,Q,T,N,R,K,E,V 555 R ARG964:A 0.675 3 0.476, 0.969 3,2 74/74 F,S,T,N,K,E,Y,V,H,Q,M,D,C,R,G,L 556 F PHE965:A -1.183 9 -1.299,-1.126 9,9 74/74 F,S,T,L 557 K LYS966:A 0.170 4 -0.090, 0.476 5,3 74/74 A,S,T,N,K,P,E,Q,D,R,G 558 L LEU967:A -1.015 8 -1.126,-0.937 9,8 74/74 F,M,I,L 559 I ILE968:A -0.411 6 -0.592,-0.285 7,6 74/74 S,A,T,K,E,V,Q,R,I 560 S SER969:A 0.141 5 -0.090, 0.476 5,3 74/74 A,S,T,N,K,V,Q,D,R,I,G 561 P PRO970:A -0.001 5 -0.285, 0.153 6,4 74/74 S,T,N,P,Y,V,H,C,R,G 562 I ILE971:A -0.492 7 -0.719,-0.285 7,6 74/74 F,Q,M,I,L,Y,V 563 S SER972:A -0.101 5 -0.285, 0.153 6,4 74/74 A,S,T,N,P,Y,H,Q,R,G 564 L LEU973:A -0.284 6 -0.450,-0.090 6,5 72/74 A,F,T,V,M,C,I,L 565 M MET974:A -0.614 7 -0.719,-0.450 7,6 74/74 S,A,T,N,E,H,Q,M,I 566 N ASN975:A -0.299 6 -0.450,-0.090 6,5 74/74 S,F,N,V,H,Q,M,C,G,L 567 M MET976:A -0.635 7 -0.833,-0.450 8,6 74/74 M,T,N,R,I,L,V 568 V VAL977:A -0.632 7 -0.833,-0.450 8,6 74/74 S,A,T,N,V,H,M,C,I,G 569 A ALA978:A -0.502 7 -0.719,-0.285 7,6 69/74 A,F,M,I,L 570 F PHE979:A 0.203 4 -0.090, 0.476 5,3 74/74 F,A,S,K,E,Y,V,H,Q,M,C,D,I,L 571 D ASP980:A -0.105 5 -0.285, 0.153 6,4 74/74 S,N,K,E,H,Q,D,G 572 P PRO981:A 0.978 2 0.476, 0.969 3,2 74/74 A,F,N,P,K,Y,E,H,Q,R,G 573 H HIS982:A 1.808 1 0.969, 2.250 2,1 74/74 S,F,T,N,K,E,V,Q,M,C,L,A,H,D,I,R 574 G GLY983:A -0.969 8 -1.126,-0.833 9,8 73/74 S,C,N,P,G,L 575 K LYS984:A 0.664 3 0.476, 0.969 3,2 74/74 F,A,T,N,K,E,V,Q,M,C,R,I,G 576 I ILE985:A 0.287 4 0.153, 0.476 4,3 73/74 Q,T,M,I,R,L,V 577 K LYS986:A 0.035 5 -0.090, 0.153 5,4 74/74 S,F,T,K,E,V,Q,M,R,I,L 578 K LYS987:A 0.020 5 -0.090, 0.153 5,4 74/74 S,A,T,N,K,P,E,D,R,G 579 Y TYR988:A 0.006 5 -0.450, 0.476 6,3 24/74 F,I,Y,L 580 N ASN989:A 1.437 1 0.969, 2.250 2,1 24/74 A,S,T,D,N,P,G,E,V 581 S SER990:A 0.065 5 -0.285, 0.476 6,3 24/74 H,A,S,T,D,N,K,G 582 V VAL991:A -0.062 5 -0.285, 0.153 6,4 74/74 A,P,E,Y,V,M,I,L 583 N ASN992:A 0.835 2 0.476, 0.969 3,2 74/74 S,T,N,K,Y,E,V,Q,L,A,P,H,D,R,I,G 584 E GLU993:A 0.729 3 0.476, 0.969 3,2 74/74 A,S,Q,T,D,P,K,G,E 585 I ILE994:A -0.497 7 -0.719,-0.285 7,6 74/74 F,A,M,C,I,Y,L,V 586 L LEU995:A -0.246 6 -0.450,-0.090 6,5 74/74 A,F,T,M,I,L,V 587 S SER996:A 2.069 1 2.250, 2.250 1,1 74/74 A,F,S,T,N,K,Y,E,V,H,Q,D,I,R 588 E GLU997:A 0.742 3 0.476, 0.969 3,2 74/74 A,S,W,N,Y,E,V,H,Q,D,I,L 589 F PHE998:A -0.438 6 -0.592,-0.285 7,6 74/74 H,F,W,Y 590 Y TYR999:A 0.506 3 0.153, 0.969 4,2 74/74 F,W,C,I,Y,L,V 591 Y TYR1000:A 2.240 1 2.250, 2.250 1,1 74/74 S,A,W,N,P,K,Y,E,V,Q,D,R,G,L 592 V VAL1001:A -0.563 7 -0.719,-0.450 7,6 74/74 S,A,F,Y,V,H,Q,R,L 593 R ARG1002:A -1.096 9 -1.213,-1.034 9,8 74/74 A,Q,C,R 594 L LEU1003:A 1.643 1 0.969, 2.250 2,1 74/74 F,K,E,V,H,Q,C,I,R,L 595 E GLU1004:A 0.804 2 0.476, 0.969 3,2 74/74 S,T,N,K,E,V,H,Q,D,R,I,G 596 Y TYR1005:A -0.384 6 -0.592,-0.285 7,6 74/74 A,F,T,K,Y,V,I,L 597 Y TYR1006:A -0.581 7 -0.719,-0.450 7,6 74/74 I,Y,L,V 598 Q GLN1007:A 0.848 2 0.476, 0.969 3,2 74/74 S,A,T,K,E,V,Q,M,R,I,G,L 599 K LYS1008:A -0.702 7 -0.833,-0.592 8,7 74/74 A,Q,N,K,R,L,E 600 R ARG1009:A -1.105 9 -1.213,-1.034 9,8 74/74 S,Q,K,R 601 K LYS1010:A -0.492 7 -0.592,-0.285 7,6 74/74 A,S,T,K,Y,I,R,L 602 D ASP1011:A 1.525 1 0.969, 2.250 2,1 74/74 S,A,T,N,K,E,V,H,Q,M,D,R,I,L 603 H HIS1012:A 0.627 3 0.476, 0.969 3,2 74/74 F,W,T,N,Y,H,M,R,I,L 604 M MET1013:A 0.585 3 0.476, 0.969 3,2 74/74 A,F,N,K,E,V,Q,M,D,I,R,L 605 S SER1014:A -0.001 5 -0.285, 0.153 6,4 74/74 A,S,T,K,E,Y,V,H,I,L 606 E GLU1015:A 1.965 1 2.250, 2.250 1,1 74/74 S,A,T,N,K,E,Q,D,R,G 607 R ARG1016:A 0.074 5 -0.090, 0.153 5,4 74/74 S,A,N,K,E,V,H,Q,M,R,L 608 L LEU1017:A -0.366 6 -0.592,-0.285 7,6 74/74 F,A,W,T,N,Y,V,Q,M,C,I,L 609 Q GLN1018:A 1.042 2 0.969, 0.969 2,2 74/74 S,T,N,K,E,Q,C,D,R,G,L 610 W TRP1019:A 0.848 2 0.476, 0.969 3,2 74/74 A,S,W,N,K,E,H,Q,M,D,I,R,L 611 E GLU1020:A -0.497 7 -0.719,-0.285 7,6 74/74 S,Q,D,K,R,L,E 612 V VAL1021:A 0.538 3 0.153, 0.969 4,2 74/74 S,F,A,T,N,K,Y,V,H,M,D,I,G,L 613 E GLU1022:A -0.150 5 -0.285, 0.153 6,4 74/74 S,A,T,K,E,H,D,R,I,L 614 K LYS1023:A -0.467 7 -0.592,-0.285 7,6 74/74 M,K,R,I,Y,L,V 615 Y TYR1024:A -0.247 6 -0.450,-0.090 6,5 74/74 F,A,I,Y,E,L,V 616 S SER1025:A -0.154 6 -0.285, 0.153 6,4 74/74 S,T,N,K,E,Q,D,R,G,L 617 F PHE1026:A -0.608 7 -0.719,-0.450 7,6 74/74 F,S,A,T,W,N,E,V,D,R,G 618 Q GLN1027:A -0.429 6 -0.592,-0.285 7,6 74/74 Q,T,K,I,R,Y,L 619 V VAL1028:A 0.564 3 0.476, 0.969 3,2 74/74 S,A,T,N,K,V,M,R,I,L 620 K LYS1029:A -0.362 6 -0.592,-0.285 7,6 74/74 Q,M,N,R,I,K,V 621 F PHE1030:A -0.960 8 -1.034,-0.833 8,8 74/74 F,S,A,G,Y,V 622 I ILE1031:A -0.374 6 -0.592,-0.285 7,6 74/74 A,F,T,Y,V,I,R,L 623 K LYS1032:A 0.036 5 -0.285, 0.153 6,4 74/74 A,S,T,N,K,E,H,Q,D,R,I,L 624 M MET1033:A -0.336 6 -0.450,-0.090 6,5 74/74 F,A,N,K,Y,E,V,H,M,I,G,L 625 I ILE1034:A -0.693 7 -0.833,-0.592 8,7 74/74 F,S,K,I,L,V 626 I ILE1035:A -0.742 7 -0.833,-0.592 8,7 74/74 A,T,N,V,D,C,R,I,G,L 627 E GLU1036:A 0.400 4 0.153, 0.476 4,3 74/74 A,S,N,P,K,E,V,Q,D,C,L 628 K LYS1037:A -0.417 6 -0.592,-0.285 7,6 74/74 M,N,K,I,G,L,V 629 E GLU1038:A -0.585 7 -0.719,-0.450 7,6 74/74 S,T,N,K,E,V,H,Q,I,G 630 L LEU1039:A 1.436 1 0.969, 2.250 2,1 74/74 S,A,T,N,K,Y,E,H,Q,D,I,R,L 631 T THR1040:A 0.422 4 0.153, 0.476 4,3 74/74 S,T,K,E,V,D,I,R,L 632 V VAL1041:A -0.999 8 -1.126,-0.937 9,8 73/74 F,I,L,V 633 T THR1042:A 2.107 1 2.250, 2.250 1,1 67/74 F,A,S,T,N,K,E,V,H,Q,R,G,L 634 N ASN1043:A -0.625 7 -0.719,-0.450 7,6 68/74 S,A,T,N,K,G,Y 635 K LYS1044:A 1.576 1 0.969, 2.250 2,1 74/74 A,S,T,N,P,K,E,V,Q,M,D,R,G 636 P PRO1045:A 0.504 3 0.153, 0.969 4,2 74/74 A,S,T,N,P,K,E,H,Q,D,G,L 637 R ARG1046:A 0.615 3 0.476, 0.969 3,2 74/74 A,S,T,N,P,K,E,V,H,D,R,G,L 638 N ASN1047:A 1.168 1 0.969, 0.969 2,2 74/74 A,S,T,N,K,E,V,Q,D,I,R,L 639 A ALA1048:A 1.979 1 2.250, 2.250 1,1 74/74 A,S,T,K,E,V,Q,M,D,I,L 640 I ILE1049:A -0.868 8 -1.034,-0.719 8,7 74/74 A,M,T,I,K,P,L 641 I ILE1050:A 0.412 4 0.153, 0.476 4,3 74/74 S,A,T,K,E,V,H,Q,M,C,R,I,L 642 Q GLN1051:A 2.243 1 2.250, 2.250 1,1 74/74 S,A,T,N,K,P,E,V,Q,D,R,I,G,L 643 E GLU1052:A 2.194 1 2.250, 2.250 1,1 74/74 S,A,T,N,K,Y,E,V,Q,M,D,I,R,G,L 644 L LEU1053:A -0.933 8 -1.034,-0.833 8,8 74/74 M,C,I,L,V 645 E GLU1054:A 0.987 2 0.969, 0.969 2,2 74/74 S,N,K,Y,E,V,H,Q,M,C,I,R,L 646 N ASN1055:A 1.299 1 0.969, 2.250 2,1 74/74 S,A,T,N,K,E,V,Q,D,R 647 L LEU1056:A 1.118 1 0.969, 0.969 2,2 71/74 S,T,N,K,Y,E,V,H,Q,M,R,G,L 648 G GLY1057:A 1.609 1 0.969, 2.250 2,1 33/74 A,S,T,N,K,P,E,H,Q,D,G 649 F PHE1058:A -0.199 6 -0.592, 0.153 7,4 33/74 F,W,D,I,Y 650 P PRO1059:A 2.219 1 2.250, 2.250 1,1 33/74 A,T,P,K,Y,E,V,Q,D,R,I,L 651 R ARG1060:A 0.468 3 0.153, 0.969 4,2 33/74 S,A,K,P,Y,V,R,G,L 652 F PHE1061:A 1.242 1 0.476, 2.250 3,1 33/74 F,S,K,Y,E,H,M,D,I,G,L 653 N ASN1062:A 0.666 3 0.153, 0.969 4,2 33/74 A,S,N,P,K,E,H,D,L 654 K LYS1063:A 0.488 3 0.153, 0.969 4,2 33/74 S,A,N,K,V,H,M,D,R,I 655 E GLU1064:A 2.080 1 2.250, 2.250 1,1 31/74 S,A,T,N,K,P,E,V,Q,D,I,L 656 G GLY1065:A 2.058 1 2.250, 2.250 1,1 30/74 A,T,N,K,P,Y,E,D,I,G,L 657 K LYS1066:A 0.319 4 -0.090, 0.476 5,3 29/74 W,T,N,K,E,M,I,L 658 P PRO1067:A 1.739 1 0.969, 2.250 2,1 28/74 A,N,K,P,V,Q,I,G,L 659 Y TYR1068:A 2.028 1 2.250, 2.250 1,1 28/74 S,T,K,Y,E,V,H,Q,R,I,L 660 Y TYR1069:A 2.082 1 2.250, 2.250 1,1 26/74 F,A,K,E,Y,H,D,R,L 661 G GLY1070:A 1.922 1 2.250, 2.250 1,1 25/74 A,S,K,E,V,H,Q,D,I,G 662 S SER1071:A 2.075 1 2.250, 2.250 1,1 21/74 S,H,D,K,G,E 663 P PRO1072:A 2.080 1 2.250, 2.250 1,1 19/74 A,T,N,P,E,V,Q,D,R,I,G 664 N ASN1073:A 1.479 1 0.969, 2.250 2,1 19/74 A,S,D,N,P,G,E 665 D ASP1074:A 2.062 1 2.250, 2.250 1,1 18/74 A,Q,D,I,R,G,L,E 666 E GLU1075:A 0.605 3 -0.090, 0.969 5,2 18/74 A,F,E,Y,V,Q,D,G 667 I ILE1076:A 1.986 1 2.250, 2.250 1,1 17/74 Q,T,D,I,K,G,E,L,V 669 E GLU1108:A 0.708 3 0.476, 0.969 3,2 74/74 S,A,F,N,P,E,Y,Q,D,C,I,L 670 Q - 2.230 1 2.250, 2.250 1,1 74/74 F,S,A,T,N,K,Y,E,H,Q,D,I,G 671 I - 0.746 3 0.476, 0.969 3,2 74/74 A,S,F,T,N,K,E,V,Q,M,D,I,L 672 N - 0.265 4 0.153, 0.476 4,3 74/74 A,S,T,N,K,P,E,V,H,Q,D,G 673 D - 0.648 3 0.476, 0.969 3,2 74/74 S,F,A,N,P,Y,E,Q,D,R,L 674 V - 2.176 1 2.250, 2.250 1,1 74/74 A,T,N,K,P,E,V,Q,D,R,I,L 675 K - -0.938 8 -1.034,-0.833 8,8 74/74 A,S,Q,D,K,E 676 G - -0.158 6 -0.285,-0.090 6,5 74/74 S,A,T,Y,E,V,Q,D,I,G 677 A - 1.567 1 0.969, 2.250 2,1 14/74 S,A,N,P,E,V,D,G 678 T - 2.022 1 2.250, 2.250 1,1 15/74 S,A,T,N,E,Q,D,G 679 S - 1.772 1 0.969, 2.250 2,1 15/74 A,S,N,D,E,L,V 680 D - 2.115 1 2.250, 2.250 1,1 15/74 S,A,N,P,E,V,D,G 681 E - 1.525 1 0.969, 2.250 2,1 15/74 S,N,D,G,E 682 E - 1.924 1 2.250, 2.250 1,1 15/74 S,Q,D,N,I,E,V 683 D - 1.678 1 0.969, 2.250 2,1 15/74 S,T,N,D,P,E 684 E - 1.459 1 0.969, 2.250 2,1 15/74 A,S,Q,K,E 685 E - 2.145 1 2.250, 2.250 1,1 15/74 S,A,P,K,E,V,Q,D,I,L 686 S - 1.566 1 0.969, 2.250 2,1 15/74 A,S,T,D,N,I,E 687 S - 1.672 1 0.969, 2.250 2,1 14/74 A,S,Q,K,G,E,L 688 H - 2.049 1 2.250, 2.250 1,1 14/74 S,K,P,E,V,H,D,I 689 E - 2.067 1 2.250, 2.250 1,1 14/74 S,A,T,P,K,E,D,I,G 690 D - 1.359 1 0.476, 2.250 3,1 13/74 A,S,T,P,E,V,D,L 691 T - 1.902 1 2.250, 2.250 1,1 13/74 A,T,D,K,P,G,E,V 692 E - 1.372 1 0.476, 2.250 3,1 13/74 S,T,D,P,E 693 N - 1.968 1 2.250, 2.250 1,1 12/74 S,Q,D,N,K,P,G,E 694 V - 1.299 1 0.476, 2.250 3,1 8/74 A,S,T,K,E,V 695 I - 0.684 3 -0.090, 0.969 5,2 8/74 S,A,Q,I,V 696 N - 0.418 4* -0.285, 0.969 6,2 9/74 F,S,H,N,Y,L 697 G - 1.763 1 0.969, 2.250 2,1 9/74 S,Q,N,K,G,V 698 P - 0.430 4* -0.285, 0.969 6,2 9/74 S,Q,K,P,E 699 E - 0.870 2 0.153, 2.250 4,1 9/74 K,G,L,Y,E 700 E GLU1109:A 0.245 4 -0.285, 0.476 6,3 9/74 A,T,K,I,E 701 L LEU1110:A 1.541 1 0.969, 2.250 2,1 10/74 T,D,P,I,E,L 702 Y TYR1111:A 1.810 1 0.969, 2.250 2,1 12/74 S,F,Q,W,G,L,Y,V 703 G GLY1112:A 0.578 3 -0.090, 0.969 5,2 15/74 S,D,N,K,P,G 704 T THR1113:A 0.663 3 0.153, 0.969 4,2 20/74 A,S,T,N,K,E,Q,C,D,G 705 Y TYR1114:A -0.675 7 -0.937,-0.450 8,6 24/74 F,Y 706 E GLU1115:A 0.029 5 -0.090, 0.153 5,4 74/74 Q,T,N,D,R,K,G,E 707 Y TYR1116:A -1.006 8 -1.126,-0.937 9,8 74/74 H,S,A,D,Y,V 708 L LEU1117:A -1.031 8 -1.126,-0.937 9,8 74/74 I,L,V 709 L LEU1118:A -1.014 8 -1.126,-0.937 9,8 74/74 F,T,L,V 710 G GLY1119:A 0.585 3 0.476, 0.969 3,2 74/74 A,S,T,N,K,E,Q,M,D,R,G 711 M MET1120:A -0.665 7 -0.833,-0.592 8,7 74/74 M,T,K,I,L 712 R ARG1121:A -0.136 5 -0.285, 0.153 6,4 74/74 A,S,T,P,K,Q,R,G 713 I ILE1122:A -0.809 8 -0.937,-0.719 8,7 74/74 A,M,I,L,V 714 W TRP1123:A 0.161 4 -0.090, 0.476 5,3 74/74 A,F,S,W,T,K,Y,H,Q,I,R,G,L 715 S SER1124:A -0.171 6 -0.285,-0.090 6,5 74/74 F,A,S,T,N,K,Y,E,H,Q,M,D,R 716 L LEU1125:A -0.991 8 -1.126,-0.937 9,8 74/74 F,I,Y,L 717 T THR1126:A -1.078 9 -1.126,-1.034 9,8 74/74 S,A,Q,T,R,L 718 K LYS1127:A 0.797 2 0.476, 0.969 3,2 74/74 A,S,N,K,E,Y,V,H,Q,I,R,G,L 719 E GLU1128:A -0.963 8 -1.126,-0.833 9,8 74/74 A,M,T,D,I,E,L 720 R ARG1129:A -0.687 7 -0.833,-0.592 8,7 74/74 S,A,N,D,K,R,E 721 Y TYR1130:A 0.538 3 0.153, 0.969 4,2 74/74 F,A,T,K,Y,E,V,H,Q,M,I,R,G,L 722 Q GLN1131:A 2.080 1 2.250, 2.250 1,1 74/74 F,T,N,K,E,V,H,Q,M,D,G 723 K LYS1132:A 0.073 5 -0.090, 0.153 5,4 74/74 S,A,T,N,K,E,V,Q,D,R 724 L LEU1133:A -0.434 6 -0.592,-0.285 7,6 74/74 F,R,I,L,V 725 L LEU1134:A 2.159 1 2.250, 2.250 1,1 74/74 F,T,N,K,E,V,Q,M,C,R,I,L 726 K LYS1135:A 2.237 1 2.250, 2.250 1,1 74/74 S,A,T,N,K,E,Q,M,D,R,G,L 727 Q GLN1136:A -0.644 7 -0.833,-0.450 8,6 74/74 S,K,E,H,Q,D,R,L 728 K LYS1137:A 1.003 2 0.476, 0.969 3,2 74/74 S,A,F,K,Y,E,H,Q,R,I,G,L 729 Q GLN1138:A 2.237 1 2.250, 2.250 1,1 74/74 A,S,Q,T,D,N,K,G,E 730 E GLU1139:A 1.177 1 0.969, 0.969 2,2 74/74 S,T,N,K,E,H,Q,D,C,R,I 731 K LYS1140:A -0.778 8 -0.937,-0.592 8,7 74/74 T,M,K,R,I,L,V 732 E GLU1141:A 2.187 1 2.250, 2.250 1,1 74/74 F,A,S,T,K,E,V,Q,M,D,I,R,G,L 733 T THR1142:A 2.245 1 2.250, 2.250 1,1 74/74 S,A,T,N,K,E,V,Q,D,I,R,G,L 734 E GLU1143:A 0.975 2 0.476, 0.969 3,2 74/74 A,S,T,K,Y,E,V,Q,D,R,L 735 L LEU1144:A -0.675 7 -0.833,-0.592 8,7 74/74 S,T,K,Y,V,H,Q,R,I,L 736 E GLU1145:A 2.158 1 2.250, 2.250 1,1 74/74 S,A,T,N,K,E,Q,D,R,I,G,L 737 N ASN1146:A 2.217 1 2.250, 2.250 1,1 74/74 A,F,S,T,N,K,Y,E,V,Q,M,D,R,I 738 L LEU1147:A 0.031 5 -0.285, 0.153 6,4 74/74 F,A,S,Y,V,M,C,I,L 739 L LEU1148:A 1.701 1 0.969, 2.250 2,1 74/74 A,S,N,K,E,V,Q,I,R,L 740 K LYS1149:A 2.246 1 2.250, 2.250 1,1 74/74 F,S,A,T,N,K,Y,E,H,Q,D,I,R,G 741 L LEU1150:A -0.320 6 -0.450,-0.090 6,5 74/74 S,A,F,T,K,V,I,L 742 S SER1151:A -0.393 6 -0.592,-0.285 7,6 74/74 S,A,T,P,V,D,I,L 743 A ALA1152:A 1.131 1 0.969, 0.969 2,2 74/74 S,A,W,T,N,P,K,E,V,Q,D,G,L 744 K LYS1153:A 0.636 3 0.476, 0.969 3,2 74/74 S,T,N,P,K,E,V,Q,D,R 745 D ASP1154:A 1.893 1 0.969, 2.250 2,1 74/74 S,A,T,N,K,P,Y,E,H,Q,M,D,R,G 746 I ILE1155:A 2.107 1 2.250, 2.250 1,1 74/74 F,A,T,N,K,Y,E,V,Q,M,D,I,R,G,L 747 W TRP1156:A -0.391 6 -0.592,-0.285 7,6 74/74 F,W,M,I,L,V 748 N ASN1157:A 1.164 1 0.969, 0.969 2,2 74/74 S,A,T,N,K,E,H,Q,C,I,R,L 749 T THR1158:A 2.035 1 2.250, 2.250 1,1 74/74 S,A,T,W,N,K,E,H,Q,D,R,G 750 D ASP1159:A -1.018 8 -1.126,-0.937 9,8 74/74 S,Q,D,N,E 751 L LEU1160:A -0.334 6 -0.592,-0.090 7,5 74/74 A,F,T,M,I,L 752 K LYS1161:A 2.065 1 2.250, 2.250 1,1 74/74 A,F,T,N,K,E,V,Q,D,I,R,G,L 753 A ALA1162:A 1.692 1 0.969, 2.250 2,1 74/74 S,A,N,K,Y,E,Q,D,R,G,L 754 F PHE1163:A 0.414 4 0.153, 0.476 4,3 74/74 F,D,I,L,Y,V 755 E GLU1164:A 0.689 3 0.476, 0.969 3,2 74/74 A,N,K,E,V,Q,M,D,R,I,G,L 756 V VAL1165:A 1.949 1 2.250, 2.250 1,1 74/74 S,A,T,N,K,E,V,H,Q,D,I,R,L 757 G GLY1166:A 0.748 3 0.476, 0.969 3,2 74/74 F,A,T,N,K,Y,E,Q,M,R,I,G 758 Y TYR1167:A 0.493 3 0.153, 0.969 4,2 74/74 H,F,W,I,L,Y,V 759 Q GLN1168:A 0.838 2 0.476, 0.969 3,2 72/74 F,S,A,N,K,E,H,Q,D,R,G 760 E GLU1169:A 0.563 3 0.476, 0.969 3,2 73/74 A,F,S,T,N,K,E,V,Q,D,G 761 F PHE1170:A 2.226 1 2.250, 2.250 1,1 73/74 F,S,A,T,N,K,P,Y,E,V,H,Q,D,I,L 762 L LEU1171:A -0.897 8 -1.034,-0.833 8,8 73/74 Q,W,D,R,L,E 763 Q GLN1172:A -0.086 5 -0.285, 0.153 6,4 71/74 A,N,P,K,E,Q,M,D,R,L 764 R ARG1173:A -0.407 6 -0.592,-0.285 7,6 67/74 A,S,T,K,P,E,V,Q,M,R 765 D ASP1174:A 1.738 1 0.969, 2.250 2,1 65/74 A,F,S,T,K,P,Y,E,V,Q,M,D,R,L 766 A ALA1175:A -0.108 5 -0.285, 0.153 6,4 63/74 A,F,K,E,V,M,I,R,L 767 E GLU1176:A 2.115 1 2.250, 2.250 1,1 55/74 A,F,S,T,E,V,Q,C,D,R,I 768 A ALA1177:A 1.260 1 0.969, 2.250 2,1 48/74 A,N,P,Y,E,V,Q,D,R,G,L 769 R ARG1178:A 1.550 1 0.969, 2.250 2,1 46/74 S,F,A,T,N,E,V,Q,D,R,L 770 G - 2.226 1 2.250, 2.250 1,1 46/74 S,A,N,P,Y,E,H,Q,M,D,R,I,G,L 771 G - 2.075 1 2.250, 2.250 1,1 42/74 A,S,T,N,K,E,Q,D,R,G 772 N - 2.219 1 2.250, 2.250 1,1 41/74 S,F,A,T,N,K,E,V,Q,D,R,I,G,L 773 V - 1.953 1 2.250, 2.250 1,1 38/74 A,N,K,E,V,Q,M,D,R,I,G,L 774 P - 2.151 1 2.250, 2.250 1,1 40/74 S,A,T,N,P,K,Y,E,V,M,D,I,L 775 N - 1.705 1 0.969, 2.250 2,1 37/74 A,F,S,T,N,K,E,V,Q,M,D,I,G,L 776 K - 0.875 2 0.476, 0.969 3,2 34/74 A,S,Q,T,D,K,G,E,V 777 G - 1.266 1 0.476, 2.250 3,1 31/74 A,S,T,N,P,K,E,V,Q,M,D,I,G 778 S - 0.830 2 0.476, 0.969 3,2 30/74 A,S,T,K,E,H,Q,R,I,L 779 K - -0.022 5 -0.285, 0.153 6,4 33/74 S,A,T,K,E,Q,D,R,G 780 T - 1.387 1 0.969, 2.250 2,1 32/74 S,A,F,T,K,V,M,I,G,L 781 K - -0.034 5 -0.285, 0.153 6,4 32/74 A,Q,T,M,N,R,K,I 782 G - 1.249 1 0.476, 2.250 3,1 32/74 A,T,N,K,P,E,V,Q,I,G 783 K - 1.903 1 2.250, 2.250 1,1 32/74 F,A,T,N,P,K,E,H,Q,D,R,G 784 G - -0.090 5 -0.450, 0.153 6,4 32/74 S,A,D,R,K,G,E 785 K - 1.633 1 0.969, 2.250 2,1 29/74 A,S,T,N,K,P,E,Q,D,R,G 786 R - 0.858 2 0.476, 0.969 3,2 27/74 A,T,K,P,V,M,I,R 787 K - 0.652 3 0.153, 0.969 4,2 26/74 A,S,T,P,K,V,M,I,G,L 788 L - 0.525 3 0.153, 0.969 4,2 26/74 S,A,T,K,V,M,I,R,L 789 V - 1.749 1 0.969, 2.250 2,1 24/74 S,A,T,K,V,M,I,G,L 790 D - 1.463 1 0.969, 2.250 2,1 23/74 F,S,T,P,K,V,M,C,D,I,L 791 D - -0.101 5 -0.450, 0.153 6,4 22/74 S,T,D,P,R,K,E 792 E - 0.506 3 0.153, 0.969 4,2 20/74 H,D,P,R,K,Y,E 793 D - 0.982 2 0.476, 2.250 3,1 18/74 S,A,N,K,Q,M,D,L *Below the confidence cut-off - The calculations for this site were performed on less than 6 non-gaped homologue sequences, or the confidence interval for the estimated score is equal to- or larger than- 4 color grades.